Review
doi: 10.1016/j.micinf.2018.12.004.
Epub 2019 Jan 21.
Inhibition of antigen presentation by Brucella: many more than many ways
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- PMID: 30677519
- DOI: 10.1016/j.micinf.2018.12.004
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Review
Inhibition of antigen presentation by Brucella: many more than many ways
Microbes Infect.
2019 Apr-May.
Free article
Abstract
Brucella infection activates the immune system and favors the differentiation of CD4+ and CD8+ T cells. To persist during a long time inside macrophages evading immune surveillance of these T cells the pathogen must exploit different evasion strategies. We review the mechanisms whereby Brucella, through TLR signaling, inhibits MHC class I and II antigen presentation, allowing infected macrophages to become effective niches for Brucella survival.
Keywords: Antigen presentation; Brucella; Macrophages; TLR.
Copyright © 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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