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Review
. 1988;14(2-3):533-8.

Mutations in ras genes in myelocytic leukemias and myelodysplastic syndromes

Affiliations
  • PMID: 3067784
Review

Mutations in ras genes in myelocytic leukemias and myelodysplastic syndromes

C R Bartram. Blood Cells. 1988.

Abstract

Acute myelocytic leukemias (AML) are characterized by a remarkably high incidence (approximately 30%) of point mutations affecting codons 12, 13, or 61 within ras genes. A predominant involvement of N-ras sequences has been established. Neither Philadelphia chromosome-positive chronic myelocytic leukemia nor other chronic myeloproliferative disorders show a similar frequency. However, a proportion of myelodysplastic syndromes, namely, the chronic myelomonocytic subtype (CMML) also show this molecular feature. The following is a brief discussion of the possible biologic and clinical implications of these observations.

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