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. 2019 Jun;94(2):155-156.
doi: 10.1016/j.diagmicrobio.2018.12.003. Epub 2018 Dec 8.

In vitro evaluation of antifungal combination against Cryptococcus neoformans

Luana Rossato  1 , Erico S Loreto  2 , Tarcieli P Venturini  3 , Maria Isabel Azevedo  4 , Abdullah M S Al-Hatmi  5 , Janio M Santurio  6 , Sydney H Alves  3
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In vitro evaluation of antifungal combination against Cryptococcus neoformans

Luana Rossato et al. Diagn Microbiol Infect Dis. 2019 Jun.

Abstract

This study evaluated combinations of amphotericin B with anidulafungin, caspofungin, and micafungin against 30 clinical isolates of Cryptococcus neoformans following the CLSI M27-A3 and the checkerboard microdilution method. The combination amphotericin B + micafungin showed 60% of synergistic effect against C. neoformans, while most of the other interactions were indifferent.

Keywords: Amphotericin B; Anidulafungin; Caspofungin; Cryptococcus spp.; Micafungin; Synergism.

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