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Review
. 2019 Feb;17(2):1085-1090.
doi: 10.3892/etm.2018.6986. Epub 2018 Nov 16.

Significance and impact of dietary factors on systemic lupus erythematosus pathogenesis

Maria-Magdalena Constantin  1   2 , Iuliana Elena Nita  2 , Rodica Olteanu  2 , Traian Constantin  1 , Stefana Bucur  2 , Clara Matei  1 , Anca Raducan  3
Affiliations
Review

Significance and impact of dietary factors on systemic lupus erythematosus pathogenesis

Maria-Magdalena Constantin et al. Exp Ther Med. 2019 Feb.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology, although its mechanisms involve genetic, epigenetic and environmental risk factors. Considering that SLE pathogenesis is yet to be explored, recent studies aimed to investigate the impact of diet, in terms of triggering or altering the course of the disease. To study the impact of diet on SLE pathogenesis, we conducted a search on Pubmed using the keywords 'diet and autoimmune diseases', 'diet and lupus', 'caloric restriction and lupus', 'polyunsaturated fatty acids and lupus', 'vitamin D and lupus', 'vitamin C and lupus' 'vitamin E and lupus' 'vitamin A and lupus' 'vitamin B and lupus', 'polyphenols and lupus', 'isoflavones and lupus', 'minerals and lupus', 'aminoacids and lupus', 'curcumin and lupus' and found 10,215 papers, from which we selected 47 relevant articles. The paper clearly emphasizes the beneficial role of personalized diet in patients with SLE, and the information presented could be used in daily practice. Proper diet in SLE can help preserve the body's homeostasis, increase the period of remission, prevent adverse effects of medication and improve the patient's physical and mental well-being.

Keywords: aminoacids; autoimmune diseases; caloric restriction; diet; minerals; systemic lupus erythematosus.

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References

    1. Kamen DL. Environmental influences on systemic lupus erythematosus expression. Rheum Dis Clin North Am. 2014;40:401–412. doi: 10.1016/j.rdc.2014.05.003. - DOI - PMC - PubMed
    1. Mu Q, Zhang H, Luo XM. SLE:Another Autoimmune Disorder Influenced by Microbes and Diet? Front Immunol. 2015;6:608. doi: 10.3389/fimmu.2015.00608. - DOI - PMC - PubMed
    1. Kamada N, Seo SU, Chen GY, Núñez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol. 2013;13:321–335. doi: 10.1038/nri3430. - DOI - PubMed
    1. Hevia A, Milani C, López P, Cuervo A, Arboleya S, Duranti S, Turroni F, González S, Suárez A, Gueimonde M, et al. Intestinal dysbiosis associated with systemic lupus erythematosus. MBio. 2014;5:e01548–e14. doi: 10.1128/mBio.01548-14. doi: 10.1128/mBio.01548-14. - DOI - PMC - PubMed
    1. Vieira SM, Pagovich OE, Kriegel MA. Diet, microbiota and autoimmune diseases. Lupus. 2014;23:518–526. doi: 10.1177/0961203313501401. - DOI - PMC - PubMed