Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb;17(2):1125-1127.
doi: 10.3892/etm.2018.7055. Epub 2018 Dec 5.

Progesterone hypersensitivity: Case report with favorable evolution

Simona C Senila  1 , Loredana Ungureanu  1 , Elisabeta Candrea  1 , Sorina Danescu  1 , Alina Vasilovici  1 , Rodica Cosgarea  1 , Vlad Dionisie  2
Affiliations

Progesterone hypersensitivity: Case report with favorable evolution

Simona C Senila et al. Exp Ther Med. 2019 Feb.

Abstract

Progesterone hypersensitivity or autoimmune progesterone dermatitis is characterized by heterogeneous skin eruptions that cyclically aggravate during the second half of the menstrual cycle, corresponding to a rise in the progesterone level. Clinical presentation is highly variable and includes all urticaria manifestations with or without angioedema, vesiculobullous, eczematous, purpuric or target-like lesions on the skin and mucous membrane. Both endogenous progesterone as well as exogenous progestogens may represent an initial trigger. We report a case of progesterone hypersensitivity in a 27-year old woman with favorable evolution only on topical therapy, the positive clinical outcome being maintained during a subsequent pregnancy and postpartum period.

Keywords: pregnancy; progesterone hypersensitivity; treatment.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Cutaneous manifestations of progesterone hypersensitivity: Erythemato-edematous papules and plaques, target-like lesions accompanied by pruritus, localized on the lower limbs, presternal area and face.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Gheorghe I, Tatu AL, Lupu I, Thamer O, Cotar AI, Pircalabioru GG, Popa M, Cristea VC, Lazar V, Chifiriuc MC. Molecular characterization of virulence and resistance features in Staphylococcus aureus clinical strains isolated from cutaneous lesions in patients with drug adverse reactions. Rom Biotechnol Lett. 2017;22:12321–12327.
    1. Raţiu MP, Purcărea I, Popa F, Purcărea VL, Purcărea TV, Lupuleasa D, Boda D. Escaping the economic turn down through performing employees, creative leaders and growth driver capabilities in the Romanian pharmaceutical industry. Farmacia. 2011;59:119–130.
    1. Hart R. Autoimmune progesterone dermatitis. Arch Dermatol. 1977;113:426–430. doi: 10.1001/archderm.113.4.426. - DOI - PubMed
    1. Nguyen T, Razzaque Ahmed A. Autoimmune progesterone dermatitis: Update and insights. Autoimmun Rev. 2016;15:191–197. doi: 10.1016/j.autrev.2015.11.003. - DOI - PubMed
    1. Mbonile L. Autoimmune progesterone dermatitis: Case report with history of urticaria, petechiae and palpable pinpoint purpura triggered by medical abortion. S Afr Med J. 2016;106:48–50. doi: 10.7196/SAMJ.2016.v106i4.9896. - DOI - PubMed