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. 2019 Feb;17(2):1125-1127.
doi: 10.3892/etm.2018.7055. Epub 2018 Dec 5.

Progesterone hypersensitivity: Case report with favorable evolution

Simona C Senila  1 , Loredana Ungureanu  1 , Elisabeta Candrea  1 , Sorina Danescu  1 , Alina Vasilovici  1 , Rodica Cosgarea  1 , Vlad Dionisie  2
Affiliations

Progesterone hypersensitivity: Case report with favorable evolution

Simona C Senila et al. Exp Ther Med. 2019 Feb.

Abstract

Progesterone hypersensitivity or autoimmune progesterone dermatitis is characterized by heterogeneous skin eruptions that cyclically aggravate during the second half of the menstrual cycle, corresponding to a rise in the progesterone level. Clinical presentation is highly variable and includes all urticaria manifestations with or without angioedema, vesiculobullous, eczematous, purpuric or target-like lesions on the skin and mucous membrane. Both endogenous progesterone as well as exogenous progestogens may represent an initial trigger. We report a case of progesterone hypersensitivity in a 27-year old woman with favorable evolution only on topical therapy, the positive clinical outcome being maintained during a subsequent pregnancy and postpartum period.

Keywords: pregnancy; progesterone hypersensitivity; treatment.

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Figures

Figure 1.
Figure 1.
Cutaneous manifestations of progesterone hypersensitivity: Erythemato-edematous papules and plaques, target-like lesions accompanied by pruritus, localized on the lower limbs, presternal area and face.
See this image and copyright information in PMC

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