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Comment
. 2016 Jun;5(Suppl 1):S54-S60.
doi: 10.21037/tcr.2016.06.12.

Microtubule targeting agents in glioma

Anda-Alexandra Calinescu  1 , Maria G Castro  1   2
Affiliations
Comment

Microtubule targeting agents in glioma

Anda-Alexandra Calinescu et al. Transl Cancer Res. 2016 Jun.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Chemical structures of selected microtubule-binding agents used for the treatment of CNS malignancies. CNS, central nervous system.
Figure 2
Figure 2
Schematic depicting proposed mechanism of action of the different classes of microtubule targeting agents. At high dose combretastatins and vinca alcaloids induce microtubule (MT) depolimerization, whereas taxols and epothilones promote microtubule polymerization; at low dose, all microtubule-binding agents inhibit microtubule dynamics, prevent the proper alignment of chromosomes at the metaphase plate and segregation of chromosomes in anaphase, leading to mitotic arrest and apoptosis.
See this image and copyright information in PMC

Comment on

References

    1. Jordan MA, Wendell K, Gardiner S, et al. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996;56:816–25. - PubMed
    1. Dumontet C, Jordan MA. Microtubule-binding agents: a dynamic field of cancer therapeutics. Nat Rev Drug Discov 2010;9:790–803. - PMC - PubMed
    1. Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer 2004;4:253–65. - PubMed
    1. Nogales E, Wolf SG, Khan IA, et al. Structure of tubulin at 6.5 A and location of the taxol-binding site. Nature 1995;375:424–7. - PubMed
    1. Rajak H, Dewangan PK, Patel V, et al. Design of combretastatin A-4 analogs as tubulin targeted vascular disrupting agent with special emphasis on their cis-restricted isomers. Curr Pharm Des 2013;19:1923–55. - PubMed

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