Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Mar;38(3):457-465.
doi: 10.1007/s10096-018-03443-5. Epub 2019 Jan 24.

Prognostic roles of time to positivity of blood culture in children with Streptococcus pneumoniae bacteremia

Qinyuan Li  1   2 , Yuanyuan Li  1   2 , Qian Yi  1   2 , Fengtao Suo  1   2 , Yuan Tang  1   2 , Siying Luo  1   2 , Xiaoyin Tian  3 , Guangli Zhang  3 , Dapeng Chen  4 , Zhengxiu Luo  5
Affiliations

Prognostic roles of time to positivity of blood culture in children with Streptococcus pneumoniae bacteremia

Qinyuan Li et al. Eur J Clin Microbiol Infect Dis. 2019 Mar.

Abstract

We aimed to investigate the relationship between time to positivity (TTP) of blood cultures and clinical outcomes in children with S. pneumoniae bacteremia. Children with S. pneumoniae bacteremia hospitalized in Children's Hospital of Chongqing Medical University from May 2011 to December 2017 were enrolled retrospectively. Overall, 136 children with S. pneumoniae bacteremia were enrolled. The standard cutoff TTP was 12 h. We stated that in-hospital mortality is significantly higher in the early TTP (≤ 12 h) group than that in the late TTP (> 12 h) group (41.70% vs 8.00%, P < 0.001). Septic shock occurred in 58.30% of patients with early TTP and in 21.00% of patients with late TTP (P < 0.001). Independent risk factors of in-hospital mortality and septic shock in children with S. pneumoniae bacteremia included early TTP, need for invasive mechanical ventilation, and PRISM III score ≥ 10. Overall, TTP ≤ 12 h appeared to associate with the worse outcomes for children with S. pneumoniae bacteremia.

Keywords: Bacteremia; Blood culture; Children; Outcomes; Streptococcus pneumoniae; Time to positivity.

PubMed Disclaimer

References

    1. Clin Infect Dis. 2001 Oct 15;33(8):1324-8 - PubMed
    1. Acta Paediatr Taiwan. 2001 Nov-Dec;42(6):333-7 - PubMed
    1. J Clin Microbiol. 2002 Mar;40(3):898-901 - PubMed
    1. Stat Med. 2002 Oct 30;21(20):3093-106 - PubMed
    1. Cancer. 1950 Jan;3(1):32-5 - PubMed

MeSH terms

LinkOut - more resources