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Review
. 2019 Jan;74(1):47-53.

[Pattern of biological changes in interstitial lung diseases]

[Article in French]
F Gester  1 , B Duysinx  1 , C Von Frenckell  2 , R Louis  1 , J Guiot  1
Affiliations
  • PMID: 30680974
Free article
Review

[Pattern of biological changes in interstitial lung diseases]

[Article in French]
F Gester et al. Rev Med Liege. 2019 Jan.
Free article

Abstract
in English, French

Interstitial lung diseases (ILD) are a part of a vast and heterogeneous clinicopathological entity. The work-up have to rule out a granulomatosis or a secondary cause, before making the diagnosis of an idiopathic ILD. The etiological diagnosis is based on a multidisciplinary approach integrating a network of clinical and paraclinical datas. If the diagnosis remains unclear, a lung biopsy is suggested with a transbronchial approach (mainly cryobiopsy) or with a surgical approach (video-assisted thoracoscopy). This review article mainly describes the biological analyses that contribute to explore ILDs.

Les pathologies infiltrantes diffuses pulmonaires (PID) font partie d’une entité clinico-pathologique vaste et hétérogène. L’enjeu de la mise au point est d’exclure une granulomatose ou une étiologie secondaire, qu’elle soit de cause connue ou inconnue, avant de conclure à une PID idiopathique. Le diagnostic étiologique repose sur une approche multidisciplinaire intégrant un faisceau d’arguments issus de l’évaluation clinique et paraclinique. En cas de doute diagnostique, une biopsie pulmonaire est proposée par voie endotrachéale de type cryobiopsie ou par voie chirurgicale vidéo-assistée. Cette revue de littérature met principalement en exergue les éléments à rechercher d’un point de vue biologique chez un patient atteint d’une PID.

Keywords: Autoantibodies; Lung biopsy; Pulmonary Fibrosis; Interstitial lung disease.

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