The Splicing Code Goes Deep

Suying Bao¹, Daniel F Moakley¹, Chaolin Zhang²

Affiliations

¹ Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
² Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA. Electronic address: cz2294@columbia.edu.

PMID: 30682368
DOI: 10.1016/j.cell.2019.01.013

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The Splicing Code Goes Deep

Suying Bao et al. Cell. 2019.

Free article

. 2019 Jan 24;176(3):414-416.

doi: 10.1016/j.cell.2019.01.013.

Authors

Suying Bao¹, Daniel F Moakley¹, Chaolin Zhang²

Affiliations

¹ Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
² Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA. Electronic address: cz2294@columbia.edu.

PMID: 30682368
DOI: 10.1016/j.cell.2019.01.013

Abstract

The importance of genomic sequence context in generating transcriptome diversity through RNA splicing is independently unmasked by two studies in this issue (Jaganathan et al., 2019; Baeza-Centurion et al., 2019).

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Predicting Splicing from Primary Sequence with Deep Learning.
Jaganathan K, Kyriazopoulou Panagiotopoulou S, McRae JF, Darbandi SF, Knowles D, Li YI, Kosmicki JA, Arbelaez J, Cui W, Schwartz GB, Chow ED, Kanterakis E, Gao H, Kia A, Batzoglou S, Sanders SJ, Farh KK. Jaganathan K, et al. Cell. 2019 Jan 24;176(3):535-548.e24. doi: 10.1016/j.cell.2018.12.015. Epub 2019 Jan 17. Cell. 2019. PMID: 30661751
Combinatorial Genetics Reveals a Scaling Law for the Effects of Mutations on Splicing.
Baeza-Centurion P, Miñana B, Schmiedel JM, Valcárcel J, Lehner B. Baeza-Centurion P, et al. Cell. 2019 Jan 24;176(3):549-563.e23. doi: 10.1016/j.cell.2018.12.010. Epub 2019 Jan 17. Cell. 2019. PMID: 30661752

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The Splicing Code Goes Deep

Affiliations

The Splicing Code Goes Deep

Authors

Affiliations

Abstract

Comment on

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MeSH terms

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