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Comment
. 2019 Jan 24;176(3):416-418.
doi: 10.1016/j.cell.2018.12.025.

Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues

Thomas Korn  1
Affiliations
Comment

Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues

Thomas Korn. Cell. .

Abstract

By in vivo screening in zebrafish larvae, Wheeler et al. identify environmental agents that directly modulate transcriptional programs of astrocytes. The herbicide linuron exploits the unfolded protein response pathway to induce a pro-inflammatory program in reactive astrocytes that potentiates inflammatory tissue damage in the CNS.

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Comment on

  • Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation.
    Wheeler MA, Jaronen M, Covacu R, Zandee SEJ, Scalisi G, Rothhammer V, Tjon EC, Chao CC, Kenison JE, Blain M, Rao VTS, Hewson P, Barroso A, Gutiérrez-Vázquez C, Prat A, Antel JP, Hauser R, Quintana FJ. Wheeler MA, et al. Cell. 2019 Jan 24;176(3):581-596.e18. doi: 10.1016/j.cell.2018.12.012. Epub 2019 Jan 17. Cell. 2019. PMID: 30661753 Free PMC article.

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