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Case Reports
. 2019 Feb 12;3(3):237-241.
doi: 10.1182/bloodadvances.2018023176.

Successful in utero stem cell transplantation in X-linked severe combined immunodeficiency

Alessandra Magnani  1   2 , Jean-Marie Jouannic  3 , Jérémie Rosain  4   5 , Aurélie Gabrion  1   2 , Fabien Touzot  6 , Cécile Roudaut  1   2 , Sven Kracker  2 , Nizar Mahlaoui  5   7   8 , Antoine Toubert  9   10   11 , Emmanuel Clave  9   10 , Elisabeth A Macintyre  12   13 , Isabelle Radford-Weiss  14 , Marion Alcantara  12   13 , Elisa Magrin  1   2 , Brigitte Ternaux  1 , Jennifer Nisoy  1 , Laure Caccavelli  1   2 , Anne-Marie Darras  3 , Capucine Picard  4   5   7   15 , Stéphane Blanche  5   7 , Marina Cavazzana  1   2   5
Affiliations
Case Reports

Successful in utero stem cell transplantation in X-linked severe combined immunodeficiency

Alessandra Magnani et al. Blood Adv. .

Abstract

  1. IUT enables rapid immune reconstitution and avoids many clinical and economic problems; however, the indication is still limited.

  2. IUT may be a treatment option in select cases, eg, fetuses exposed to a significant infectious risk, where a matched sibling donor exists.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
Immune reconstitution after birth. (A) CD3+, CD4+, CD8+, CD31+CD45RA+CD4+, CD19+, and CD56+ cell counts. (B) Immunoglobulin A (IgA), IgM, and IgG reconstitution. (C) TRECs. Dots correspond to the values recorded. The lower and upper boundaries of the age-specific normal range are indicated by solid and dashed lines, respectively.
See this image and copyright information in PMC

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