Injectable thermosensitive hydrogel systems based on functional PEG/PCL block polymer for local drug delivery

Abstract

Injectable in situ thermosensitive hydrogels have potential applications in tissue engineering and drug delivery. The hydrogel formulations exist as aqueous solutions at room temperature but rapidly solidify into gels at 37 °C in situ, making them highly suitable for administering drugs in a minimally invasive manner to the target organ(s). The hydrogel formed with nanoparticles assembled with amphiphilic polymer blocks of polyethyleneglycol (PEG) and biodegradable polycaprolactone (PCL) have been tested as platforms for targeted and sustained drug delivery, and have shown encouraging results. In this review, we summarize the influence of the molecular weight, PEG/PCL ratio and functional structure of hydrophobic PCL blocks on the critical gelation temperature, gelling behavior and drug release kinetics of the hydrogels. The current studies on the biomedical applications of thermosensitive PEG/PCL hydrogels have also been discussed.

Keywords: Block copolymer; Hydrogel; Local drug delivery; Polycaprolactone (PCL); Thermosensitive.