Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jun 20;36(6):357-61.
doi: 10.1007/BF01000594.

[High-dose methotrexate/leucovorin adjuvant chemotherapy of osteogenic sarcoma: biochemical effects in DNA-synthesis of bone marrow cells (author's transl)]

[Article in German]
H Sauer, W Wilmanns

[High-dose methotrexate/leucovorin adjuvant chemotherapy of osteogenic sarcoma: biochemical effects in DNA-synthesis of bone marrow cells (author's transl)]

[Article in German]
H Sauer et al. Blut. .

Abstract

DNA metabolism in bone marrow cells was measured under high-dose Methotrexate/Leucovorin adjuvant chemotherapy of a patient with primary amputation of his right leg because of osteogenic sarcoma. The biochemical data showed that there was no rescue effect of Leucovorin after 200 mg/kg Methotrexate. Corresponding to this "biochemical failure" of the rescue effect the patient died from the complications of a long and very severe bone marrow suppression. To improve the safety of this therapeutic regimen the intravenous injection and in some cases a higher dose of Leucovorin is recommended.

PubMed Disclaimer

References

    1. Klin Wochenschr. 1967 May 15;45(10):505-11 - PubMed
    1. Cancer. 1976 Jun;37(6):2703-8 - PubMed
    1. Chirurg. 1977 Apr;48(4):274-9 - PubMed
    1. Blut. 1974 May;28(5):321-6 - PubMed
    1. J Bone Joint Surg Am. 1976 Jul;58(5):629-33 - PubMed

Publication types