Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Sep;23(3):857-863.
doi: 10.1007/s11325-018-01777-0. Epub 2019 Jan 26.

Short-term effects of continuous positive airway pressure on oxidative stress in severe sleep apnea

Ľubomíra Tóthová  1   2 , Peter Celec  1   3   4 , Imrich Mucska  5 , Július Hodosy  6   7   8
Affiliations

Short-term effects of continuous positive airway pressure on oxidative stress in severe sleep apnea

Ľubomíra Tóthová et al. Sleep Breath. 2019 Sep.

Abstract

Purpose: Obstructive sleep apnea (OSA) is associated with oxidative stress that is involved in the pathogenesis of cardiovascular and metabolic complications. The concentrations of salivary markers of oxidative stress in patients with OSA increase considerably during the night. The dynamics is not affected by continuous positive airway pressure (CPAP) in mild to moderate OSA. The aim of this study was to analyze the short-term effects of CPAP on salivary oxidative stress markers in patients with severe OSA.

Methods: Salivary samples were collected from 24 patients with apnea-hypopnea index higher than 30 during the first (diagnostic) night, who were treated by CPAP during the second (therapeutic) night.

Results: The salivary markers of oxidative stress (TBARS, AGEs, and AOPP) were higher in the morning after the diagnostic night when compared to the evening concentrations (p < 0.01 for TBARS and p < 0.05 for AGEs and AOPP). Treatment by CPAP significantly decreased the morning concentrations of TBARS, AOPP (p < 0.01 for both), and AGEs (p < 0.05). Also, TBARS and AGEs positively correlated with apnea-hypopnea index (r = 0.48 and 0.49, respectively; p < 0.05). Antioxidant statuss was not affected.

Conclusion: Severe OSA is associated with increased levels of saliva markers for lipid peroxidation, protein oxidative damage, and carbonyl damage. Even short-term CPAP partially prevents oxidative and carbonyl stress during the night and this can be monitored non-invasively using saliva.

Keywords: Lipid peroxidation; Non-invasive monitoring; Oxidative damage; Salivary biomarkers.

PubMed Disclaimer

References

    1. Lavie P, Lavie L (2008) Cardiovascular morbidity and mortality in obstructive sleep apnea. Curr Pharm Des 14:3466–3473 - DOI - PubMed
    1. Jurkovicova I, Celec P, Mucska I, Hodosy J (2003) On the origin of cardiovascular complications of sleep apnea syndrome by the means of molecular interactions. Bratisl Lek Listy 104:167–173 - PubMed
    1. Sies H, Berndt C, Jones DP (2017) Oxidative stress. Annu Rev Biochem 86:715–748 - DOI
    1. Lavie L, Vishnevsky A, Lavie P (2004) Evidence for lipid peroxidation in obstructive sleep apnea. Sleep 27:123–128 - PubMed
    1. Mancuso M, Bonanni E, LoGerfo A, Orsucci D, Maestri M, Chico L, DiCoscio E, Fabbrini M, Siciliano G, Murri L (2012) Oxidative stress biomarkers in patients with untreated obstructive sleep apnea syndrome. Sleep Med 13:632–636 - DOI - PubMed

LinkOut - more resources