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Case Reports
. 2019 Jan-Mar;24(1):68-71.
doi: 10.4103/jiaps.JIAPS_102_18.

Hepatoblastoma with Precocious Puberty

Enono Yhoshu  1 , Yasir A Lone  1 , Jai K Mahajan  1 , Umesh Bahadur Singh  1
Affiliations
Case Reports

Hepatoblastoma with Precocious Puberty

Enono Yhoshu et al. J Indian Assoc Pediatr Surg. 2019 Jan-Mar.

Abstract

Hepatoblastoma (HB), a primary liver tumor of childhood, is often accompanied by raised levels of alpha-fetoprotein (α-FP). Rarely, the beta-human chorionic gonadotropin (β-hCG) levels may also be elevated, which can cause peripheral precocious puberty (PPP). We report a case of HB with precocious puberty wherein hormonal assays showed an increase in α-FP, β-hCG, and testosterone levels, and suppression of follicle-stimulating and luteinizing hormone levels. After chemotherapy and surgery, α-FP, β-hCG, and testosterone levels normalized, and the signs of virilization did not progress further. New therapeutic approaches have made a previously reported grim prognosis of virilizing HB, more favorable now. In the assessment of PPP, the possibility of a tumoral source for the hormones should also be considered.

Keywords: Hepatoblastoma; precocious; puberty; virilization.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Patient with Tanner Stage-3 genitalia
Figure 2
Figure 2
Magnetic resonance images showing tumor in the right lobe of the liver
See this image and copyright information in PMC

References

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