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Case Reports
. 2019 Jan 3;9(3):516-519.
doi: 10.1159/000495745. eCollection 2018 Sep-Dec.

Diffuse Large B-Cell Lymphoma of the Lacrimal Sac in a Japanese Patient

Satoshi Kakutani  1 , Yasuhiro Takahashi  1 , Ma Regina Paula Valencia  1 , Hirohiko Kakizaki  1
Affiliations
Case Reports

Diffuse Large B-Cell Lymphoma of the Lacrimal Sac in a Japanese Patient

Satoshi Kakutani et al. Case Rep Ophthalmol. .

Abstract

Purpose: To report a Japanese patient with diffuse large B-cell lymphoma (DLBCL) in the lacrimal sac.

Methods: This is a case report of a 52-year-old Japanese woman who presented with a 3-month history of epiphora on the right side and a 1-month history of swelling on the right medial canthal area. Lacrimal sac irrigation showed patency of the lacrimal drainage system. Imaging studies revealed a lacrimal sac mass with involvement of the nasolacrimal duct.

Results: Histopathology and immunohistochemistry of the biopsy specimen revealed DLBCL. Systemic workup revealed no other lesion. The patient received 6 cycles of R-CHOP regimen. After completion of the 5th cycle of R-CHOP, all of the symptoms had resolved.

Conclusion: We report a case of DLBCL in the lacrimal sac, which is the most common type of lacrimal sac lymphoma in Japan. Since DLBCL is one of the aggressive types of lymphoma, Japanese patients with lacrimal sac lymphoma tend to have a poor prognosis.

Keywords: Diffuse large B-cell lymphoma; Japanese patients; Lacrimal sac.

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Figures

Fig. 1
Fig. 1
a The patient's photograph during the first examination showing a mass in the right medial canthus. b Enhanced T1-weighted axial magnetic resonance imaging showed a soft tissue mass in the lacrimal sac with heterogeneously mild enhancement. c–e Histopathological and immunostaining specimens from the lacrimal sac. c Diffuse proliferation of large lymphoid cells with high-density nuclei (hematoxylin and eosin, ×200). Immunostaining with CD20 (d) and BCL-6 (e) were both positive (×200).
See this image and copyright information in PMC

References

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