Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Jan 3;9(3):516-519.
doi: 10.1159/000495745. eCollection 2018 Sep-Dec.

Diffuse Large B-Cell Lymphoma of the Lacrimal Sac in a Japanese Patient

Satoshi Kakutani  1 , Yasuhiro Takahashi  1 , Ma Regina Paula Valencia  1 , Hirohiko Kakizaki  1
Affiliations
Case Reports

Diffuse Large B-Cell Lymphoma of the Lacrimal Sac in a Japanese Patient

Satoshi Kakutani et al. Case Rep Ophthalmol. .

Abstract

Purpose: To report a Japanese patient with diffuse large B-cell lymphoma (DLBCL) in the lacrimal sac.

Methods: This is a case report of a 52-year-old Japanese woman who presented with a 3-month history of epiphora on the right side and a 1-month history of swelling on the right medial canthal area. Lacrimal sac irrigation showed patency of the lacrimal drainage system. Imaging studies revealed a lacrimal sac mass with involvement of the nasolacrimal duct.

Results: Histopathology and immunohistochemistry of the biopsy specimen revealed DLBCL. Systemic workup revealed no other lesion. The patient received 6 cycles of R-CHOP regimen. After completion of the 5th cycle of R-CHOP, all of the symptoms had resolved.

Conclusion: We report a case of DLBCL in the lacrimal sac, which is the most common type of lacrimal sac lymphoma in Japan. Since DLBCL is one of the aggressive types of lymphoma, Japanese patients with lacrimal sac lymphoma tend to have a poor prognosis.

Keywords: Diffuse large B-cell lymphoma; Japanese patients; Lacrimal sac.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
a The patient's photograph during the first examination showing a mass in the right medial canthus. b Enhanced T1-weighted axial magnetic resonance imaging showed a soft tissue mass in the lacrimal sac with heterogeneously mild enhancement. c–e Histopathological and immunostaining specimens from the lacrimal sac. c Diffuse proliferation of large lymphoid cells with high-density nuclei (hematoxylin and eosin, ×200). Immunostaining with CD20 (d) and BCL-6 (e) were both positive (×200).
See this image and copyright information in PMC

References

    1. Sjö LD, Ralfkiaer E, Juhl BR, Prause JU, Kivelä T, Auw-Haedrich C, et al. European Organization for Research and Treatment of Cancer Primary lymphoma of the lacrimal sac: an EORTC ophthalmic oncology task force study. Br J Ophthalmol. 2006 Aug;90((8)):1004–9. - PMC - PubMed
    1. Sabundayo MS, Takahashi Y, Kakizaki H. Lacrimal sac lymphoma: A series of Japanese patients. Eur J Ophthalmol. 2018 Oct;:1120672118803510. E-pub Ahead of Print. - PubMed
    1. Kajita F, Oshitari T, Yotsukura J, Asanagi K, Baba T, Kishimoto T, et al. Case of primary diffuse large B-cell lymphoma of lacrimal sac in a Japanese patient. Clin Ophthalmol. 2010 Nov;4:1351–4. - PMC - PubMed
    1. Montalban A, Liétin B, Louvrier C, Russier M, Kemeny JL, Mom T, et al. Malignant lacrimal sac tumors. Eur Ann Otorhinolaryngol Head Neck Dis. 2010 Nov;127((5)):165–72. - PubMed
    1. Flanagan JC, Stokes DP. Lacrimal sac tumors. Ophthalmology. 1978 Dec;85((12)):1282–7. - PubMed

Publication types

LinkOut - more resources