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Review
. 2019 Jan 10:9:3112.
doi: 10.3389/fimmu.2018.03112. eCollection 2018.

Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors

Alexandre Thibault Jacques Maria  1   2   3 , Léo Partouche  1   2 , Radjiv Goulabchand  1   2 , Sophie Rivière  2 , Pauline Rozier  1   2   3 , Céline Bourgier  1   4 , Alain Le Quellec  1   2 , Jacques Morel  1   5 , Danièle Noël  3 , Philippe Guilpain  1   2   3
Affiliations
Review

Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors

Alexandre Thibault Jacques Maria et al. Front Immunol. .

Abstract

Systemic sclerosis (SSc) is an autoimmune connective tissue disorder, characterized by multisystem involvement, vasculopathy, and fibrosis. An increased risk of malignancy is observed in SSc (including breast and lung cancers), and in a subgroup of patients with specific autoantibodies (i.e., anti-RNA polymerase III and related autoantibodies), SSc could be a paraneoplastic syndrome and might be directly related to an immune response against cancer. Herein, we reviewed the literature, focusing on the most recent articles, and shed light onto the potential relationship between cancer and scleroderma regarding temporal and immunological dimensions.

Keywords: Systemic sclerosis (scleroderma); autoimmunity; cancer; immunoediting of cancer; immunosurveillance; paraneopastic syndrome.

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Figures

Figure 1
Figure 1
Complex and bilateral relationships between systemic sclerosis and cancer.
Figure 2
Figure 2
Anti-tumor driven auto-immunity: from mutated RNA polymerase III in cancer to paraneoplastic systemic sclerosis.
See this image and copyright information in PMC

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