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. 2018 Apr-Jun;44(2):118-121.
doi: 10.12865/CHSJ.44.02.04. Epub 2018 Mar 27.

Blood Coagulation Following an Acute Ischemic Stroke

M D Sfredel  1 , E Burada  1 , B Cătălin  1   2 , V Dinescu  1 , G Târtea  1 , M Iancău  1 , E Osiac  3
Affiliations

Blood Coagulation Following an Acute Ischemic Stroke

M D Sfredel et al. Curr Health Sci J. 2018 Apr-Jun.

Abstract

Objective: Hemostasis is a complex physiological process that stops bleeding at the site of a vascular injury. Although the majority of vascular accidents are ischemic, the role of hypercoagulable state and stroke needs further investigation.

Materials and methods: Fresh whole blood was taken from 61 acute ischemic stroke patients and compared to 18 healthy subjects and investigated with optical coherence tomography imaging after initiating coagulation. We used an OCT1300SS system (Thorlabs) and did 3D scans. We then processed the images with ImageJ. For each image mean, integrated density, skewness and kurtosis of gray values were analyzed.

Results: Mean gray value and integrated intensity of sampled data showed an intrinsic difference detected with OCT. This difference was further confirmed by the data distribution analysis.

Conclusions: Results suggest, that normal blood coagulation, is not a random reaction while in the case of stroke patients, the relatively symmetrical distribution of gray values brings coagulation closer randomized process.

Keywords: cerebral ischemia; coagulation; optical coherence tomography.

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Figures

Figure 1
Figure 1
Light beam penetration of blood sample differed significantly in the two analyzed groups
Figure 2
Figure 2
Analysis of gray values identifies a steady decrease of this value in control and an increase in stroke patients
Figure 3
Figure 3
The integrated density of gray values shows differences in blood clotting dynamics
Figure 4
Figure 4
The distribution of gray values revealed an asymmetry in controls, compared with stroke patients
Figure 5
Figure 5
The kurtosis of the two data sets highlights a random coagulation process in patients with stroke compared to the control group
See this image and copyright information in PMC

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