Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Apr-Jun;44(2):118-121.
doi: 10.12865/CHSJ.44.02.04. Epub 2018 Mar 27.

Blood Coagulation Following an Acute Ischemic Stroke

M D Sfredel  1 , E Burada  1 , B Cătălin  1   2 , V Dinescu  1 , G Târtea  1 , M Iancău  1 , E Osiac  3
Affiliations

Blood Coagulation Following an Acute Ischemic Stroke

M D Sfredel et al. Curr Health Sci J. 2018 Apr-Jun.

Abstract

Objective: Hemostasis is a complex physiological process that stops bleeding at the site of a vascular injury. Although the majority of vascular accidents are ischemic, the role of hypercoagulable state and stroke needs further investigation.

Materials and methods: Fresh whole blood was taken from 61 acute ischemic stroke patients and compared to 18 healthy subjects and investigated with optical coherence tomography imaging after initiating coagulation. We used an OCT1300SS system (Thorlabs) and did 3D scans. We then processed the images with ImageJ. For each image mean, integrated density, skewness and kurtosis of gray values were analyzed.

Results: Mean gray value and integrated intensity of sampled data showed an intrinsic difference detected with OCT. This difference was further confirmed by the data distribution analysis.

Conclusions: Results suggest, that normal blood coagulation, is not a random reaction while in the case of stroke patients, the relatively symmetrical distribution of gray values brings coagulation closer randomized process.

Keywords: cerebral ischemia; coagulation; optical coherence tomography.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Light beam penetration of blood sample differed significantly in the two analyzed groups
Figure 2
Figure 2
Analysis of gray values identifies a steady decrease of this value in control and an increase in stroke patients
Figure 3
Figure 3
The integrated density of gray values shows differences in blood clotting dynamics
Figure 4
Figure 4
The distribution of gray values revealed an asymmetry in controls, compared with stroke patients
Figure 5
Figure 5
The kurtosis of the two data sets highlights a random coagulation process in patients with stroke compared to the control group
See this image and copyright information in PMC

References

    1. Tanaka KA, Key NS, Levy JH. Blood coagulation: hemostasis and thrombin regulation. Anesthesia and analgesia. 2009;108(5):1433–1446. - PubMed
    1. Periayah MH, Halim AS, Mat Saad. Mechanism Action of Platelets and Crucial Blood Coagulation Pathways in Hemostasis. International journal of hematology-oncology and stem cell research. 2017;11(4):319–327. - PMC - PubMed
    1. Gale AJ. Continuing education course #2: current understanding of hemostasis. Toxicol Pathol. 2011;39(1):273–280. - PMC - PubMed
    1. Maino A, Rosendaal FR, Algra A, Peyvandi F, Siegerink B. Hypercoagulability Is a Stronger Risk Factor for Ischaemic Stroke than for Myocardial Infarction: A Systematic Review. PLoS One. 2015;10(8):e0133523–e0133523. - PMC - PubMed
    1. de Lau, Leebeek FW, de Maat, Koudstaal PJ, Dippel DW. Screening for coagulation disorders in patients with ischemic stroke. Expert review of neurotherapeutics. 2010;10(8):1321–1329. - PubMed

LinkOut - more resources