Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Apr-Jun;44(2):186-191.
doi: 10.12865/CHSJ.44.02.16. Epub 2018 Mar 27.

The Association Between Helicobacter Pylori Infection and Liver and Biliary Tract Disorders

D Popescu  1 , D Andronescu  2 , P A Babes  3
Affiliations

The Association Between Helicobacter Pylori Infection and Liver and Biliary Tract Disorders

D Popescu et al. Curr Health Sci J. 2018 Apr-Jun.

Abstract

Helicobacter Pylori (HP) persistently colonizes the stomach in about 50% of the globe population and it is the main risk factor for peptic ulcer, as well as for gastric adenocarcinoma and MALT gastric lymphoma. The treatment for HP revolutionized the management of the peptic ulcer disease, providing permanent healing in many cases. Preventing colonization of HP would be the primary prevention of gastric malignancy and peptic ulceration. At the same time, the presence of HP provides protection for some diseases (gastroesophageal reflux disease and its complications, esophageal adenocarcinoma, asthma), the eradication of the microorganism having negative repercussions. HP has an increasingly recognized role in other extragastric pathologies. Thus, immune thrombocytopenic purpura has improved after treating HP infection. There are controversial association with ischemic heart disease and cerebrovascular disease. The current article highlights an important association between HP infection and a range of hepatobiliary disorders such as biliary lithiasis (where even an etiological role is involved), cholestatic syndromes (primary sclerosing cholangitis and primary biliary cholangitis), chronic hepatitis B virus, chronic hepatitis C virus, with an evolution towards cirrhosis and hepatocellular carcinoma.

Keywords: biliary litiasis; primary biliary cholangitis; primary sclerosing cholangitis; helicobacter Pylori; hepatobiliary disorders.

PubMed Disclaimer

References

    1. Atherton JC, Blaser MJ. Helicobacter pylori Infections. In: Longo Dl, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo JL., editors. Harrison's Gastroenterology and Hepatology - 18th edition. New York: McGraw-Hill; 2010. pp. 253–259.
    1. Jemilohun AC, Otegbayo JA. Helicobacter pylori infection: past, present and future. Pan Afr Med J. 2016;23:21–21.
    1. Akopyanz N, Clifton SW, Kersulyte D, Crabtree JE, Youree BE, Reece CA, Bukanov NO, Drazek ES, Roe BA, Berg DE. Analyses of the cag pathogenicity island of Helicobacter pylori. Mol Microbiol. 1998;28:37–53. - PubMed
    1. Ohno T, Vallström A, Rugge M, Ota H, Graham DY, Arnqvist A, Yamaoka Y. Effects of Blood Group Antigen-Binding Adhesin Expression during Helicobacter Pylori Infection of Mongolian Gerbils. J Infect Dis. 2011;203(5):726–735. - PMC - PubMed
    1. Fu H-W. Helicobacter pylori neutrophil-activating protein: From molecular pathogenesis to clinical applications. World J Gastroenterol. 2014;20(18):5294–5301. - PMC - PubMed

LinkOut - more resources