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. 2018 Apr-Jun;44(2):192-196.
doi: 10.12865/CHSJ.44.02.17. Epub 2018 Mar 27.

Severe Thrombocytopenia in Patient with Dermatomyositis

A D Tudorancea  1 , P L Ciurea  1 , F A Vreju  1 , E M Vintila  2 , Ș C Dinescu  1
Affiliations

Severe Thrombocytopenia in Patient with Dermatomyositis

A D Tudorancea et al. Curr Health Sci J. 2018 Apr-Jun.

Abstract

Dermatomyositis (DM) is part of a heterogeneous group of systemic diseases called idiopathic inflammatory myopathies. As in other autoimmune connective tissue diseases (CTD), abnormalities of hematopoietic tissue and/or peripheral blood cells may develop and represent an important prognostic factor. Most common CTD associated with thrombocytopenia (TP) are systemic lupus erythematosus and antiphospholipid syndrome. DM-related TP is less frequent and may develop in the context of an underlying malignancy. Severe TP related to myositis is a very rare occurrence. We report a case of a male patient diagnosed with acute DM, debilitating muscle weakness and rapid development of severe TP.

Keywords: idiopathic inflammatory myopathies; dermatomyositis; thrombocytopenia.

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Figures

Figure 1
Figure 1
Clinical features on admission included skin changes such as heliotrope rash of the eyelids and periorbital edema
Figure 2
Figure 2
Dynamic follow-up of platelet count and serum levels of creatin kinase; although enzyme levels have a steady drop, there is an initial lack of response regarding the platelet count, with maintained thrombocytopenia after completion of first pulse therapy; platelets reach a minimum level of 28000/mm3 after 10 days of corticosteroid treatment; second pulse therapy offers greater benefit concerning both thrombocytopenia and clinical symptoms
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References

    1. Malik A, Hayat G, Kalia JS, Guzman MA. Idiopathic Inflammatory Myopathies: Clinical Approach and Management. Front Neurol. 2016;7:64–64. - PMC - PubMed
    1. Hewer E, Goebel HH. Myopathology of non-infectious inflammatory myopathies-The current status. Pathol Res Pract. 2008;204(9):609–623. - PubMed
    1. Fietta P, Delsante G, Quaini F. Hematologic manifestations of connective autoimmune diseases. Clin Exp Rheumatol. 2009;27(1):140–154. - PubMed
    1. Arkfeld DG, Weitz IC. Immune thrombocytopenia in patients with connective tissue disorders and the antiphospholipid antibody syndrome. Hematol Oncol Clin. 2009;23(6):1239–1249. - PubMed
    1. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25(11):1271–1277. - PubMed

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