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Review
. 2018 Dec 27:2018:9075174.
doi: 10.1155/2018/9075174. eCollection 2018.

Assessing the Relationship between Performance on the University of California Performance Skills Assessment (UPSA) and Outcomes in Schizophrenia: A Systematic Review and Evidence Synthesis

Shelagh Szabo  1 , Elizabeth Merikle  2 , Greta Lozano-Ortega  1 , Lauren Powell  1 , Thomas Macek  2 , Stephanie Cline  2
Affiliations
Review

Assessing the Relationship between Performance on the University of California Performance Skills Assessment (UPSA) and Outcomes in Schizophrenia: A Systematic Review and Evidence Synthesis

Shelagh Szabo et al. Schizophr Res Treatment. .

Abstract

Objective: To perform a systematic review of the published literature to evaluate how functional capacity, as measured by the University of California at San Diego (UCSD) Performance-based Skills Assessment (UPSA), relates to other functional measures and real-world outcomes among individuals with schizophrenia.

Methods: The MEDLINE® and Embase® databases were searched to identify joint evaluations with UPSA and key functional outcomes (functional scale measures; generic or disease-specific, health-related quality of life [HRQoL]; or real-world outcomes [residential status; employment status]) in patients with schizophrenia. Pearson correlations were estimated between UPSA scores, HRQoL, other functional scale measures, and real-world outcomes, for outcomes described in at least six studies.

Results: The synthesis included 76 studies that provided 73 unique data sets. Quantitative assessment between the Specific Level of Function (SLOF) (n=18) scores and UPSA scores demonstrated a moderate borderline-significant correlation (0.45, p=0.06). Quantitative analysis of the relationship between the Global Assessment of Functioning (GAF) (n=11) and the Multidimensional Scale of Independent Functioning (MSIF) (n=6) scales revealed moderate and small nonsignificant Pearson correlations of -0.34 (p=0.31) and 0.12 (p=0.83), respectively. There was a small borderline-significant correlation between UPSA score and residential status (n=36; 0.31; p=0.08), while no correlation was found between UPSA score and employment status (n=19; 0.04; p=0.88).

Conclusion: The SLOF was the most often used functional measure and had the strongest observed correlation with the UPSA. Although knowledge gaps remain, evidence from this review indicates that there is a quantitative relationship between functional capacity and real-world outcomes in individuals with schizophrenia.

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Figures

Figure 1
Figure 1
Flow chart of article screening and selection process.
Figure 2
Figure 2
Scatterplot of UPSA and scores on functional measures from studies that reported both measures.
Figure 3
Figure 3
UPSA vs residential and employment status.
Figure 4
Figure 4
The strength of correlations between UPSA and employment status, residential status, the SLOF, MSIF, and GAF. Strength of correlations indicated by a correlation coefficient (according to UPSA type, if sufficient data are available) and color. The number of studies contributing evidence to a particular relationship is indicated by the thickness of the line connecting the UPSA to each of the other measures.
See this image and copyright information in PMC

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