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Review
. 2019 Jan 9:5:329.
doi: 10.3389/fvets.2018.00329. eCollection 2018.

Methodologies for Assessing Disease Tolerance in Pigs

Dimitar Nakov  1 , Slavcha Hristov  2 , Branislav Stankovic  2 , Françoise Pol  3 , Ivan Dimitrov  4 , Vlatko Ilieski  5 , Pierre Mormede  6 , Julie Hervé  7 , Elena Terenina  6 , Blandine Lieubeau  7 , Dimitrios K Papanastasiou  8 , Thomas Bartzanas  8 , Tomas Norton  9 , Deborah Piette  9 , Emanuela Tullo  10 , Ingrid D E van Dixhoorn  11
Affiliations
Review

Methodologies for Assessing Disease Tolerance in Pigs

Dimitar Nakov et al. Front Vet Sci. .

Abstract

Features of intensive farming can seriously threaten pig homeostasis, well-being and productivity. Disease tolerance of an organism is the adaptive ability in preserving homeostasis and at the same time limiting the detrimental impact that infection can inflict on its health and performance without affecting pathogen burden per se. While disease resistance (DRs) can be assessed measuring appropriately the pathogen burden within the host, the tolerance cannot be quantified easily. Indeed, it requires the assessment of the changes in performance as well as the changes in pathogen burden. In this paper, special attention is given to criteria required to standardize methodologies for assessing disease tolerance (DT) in respect of infectious diseases in pigs. The concept is applied to different areas of expertise and specific examples are given. The basic physiological mechanisms of DT are reviewed. Disease tolerance pathways, genetics of the tolerance-related traits, stress and disease tolerance, and role of metabolic stress in DT are described. In addition, methodologies based on monitoring of growth and reproductive performance, welfare, emotional affective states, sickness behavior for assessment of disease tolerance, and methodologies based on the relationship between environmental challenges and disease tolerance are considered. Automated Precision Livestock Farming technologies available for monitoring performance, health and welfare-related measures in pig farms, and their limitations regarding DT in pigs are also presented. Since defining standardized methodologies for assessing DT is a serious challenge for biologists, animal scientists and veterinarians, this work should contribute to improvement of health, welfare and production in pigs.

Keywords: behavior; disease tolerance; environment; performance; stress.

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Figures

Figure 1
Figure 1
Quantification of performance responses after perturbations, resistance (iA and iB), recovery or halftime (τA and τB) to (new) equilibrium and robustness (equilibrium level after perturbation). [Modification Urruty et al. (7)].
Figure 2
Figure 2
Illustration of conceptual framework for assessing DT in pigs.
See this image and copyright information in PMC

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