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Randomized Controlled Trial
. 2019 May;58(5):534-540.
doi: 10.1177/0009922819826105. Epub 2019 Jan 28.

Effect of Donor Milk Supplementation on Breastfeeding Outcomes in Term Newborns: A Randomized Controlled Trial

Laura R Kair  1   2 , Valerie J Flaherman  3 , Tarah T Colaizy  1
Affiliations
Randomized Controlled Trial

Effect of Donor Milk Supplementation on Breastfeeding Outcomes in Term Newborns: A Randomized Controlled Trial

Laura R Kair et al. Clin Pediatr (Phila). 2019 May.

Abstract

Background: Pasteurized donor human milk (DHM) use for healthy newborns is increasing; however, no studies have explored its effect on breastfeeding outcomes.

Patients and methods: We enrolled 60 healthy, term breastfeeding newborns with ≥4.5% weight loss in the first 36 hours in a randomized controlled trial. Thirty newborns were randomly assigned to early limited-volume DHM supplementation and 30 newborns to exclusive breastfeeding. Mothers were surveyed at 1 week and 1, 2, and 3 months regarding the mode of infant feeding. Comparing infants randomized to DHM supplementation with those exclusively breastfeeding, there was no significant difference in the proportion using formula at 1 week (21% vs 7%, P = .15), nor in the proportion of any breastfeeding (79% vs 90%, P = .30) or breastfeeding without formula at 3 months (62% vs 77%, P = .27). Conclusion For newborns with ≥4.5% weight loss in the first 36 hours, early limited-volume supplementation with DHM is unlikely to have a significant favorable impact on breastfeeding outcomes.

Trial registration: ClinicalTrials.gov NCT02221167.

Keywords: breast milk; breastfeeding; donor human milk; donor milk; milk banking; neonate.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest relevant to this article to disclose.

Figures

Figure 1.
Figure 1.
Flow diagram for Rx Milk Trial
See this image and copyright information in PMC

References

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