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Multicenter Study
. 2019 Apr 1;30(4):652-653.
doi: 10.1093/annonc/mdz021.

Association between antibiotics use and outcome in patients with NSCLC treated with immunotherapeutics

F Huemer  1 , G Rinnerthaler  2 , D Lang  3 , H Hackl  4 , B Lamprecht  3 , R Greil  5
Affiliations
Multicenter Study

Association between antibiotics use and outcome in patients with NSCLC treated with immunotherapeutics

F Huemer et al. Ann Oncol. .
No abstract available

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Figures

Figure 1.
Figure 1.
Kaplan–Meier curves for overall survival according to the antibiotic treatment status. Comparison of Kaplan–Meier curves for overall survival between antibiotic-positive and antibiotic-negative group in advanced non-squamous non-small-cell lung cancer for the entire cohort (A), for the tertiary cancer center in Salzburg (B) and for the tertiary cancer center in Linz (C). The 95% confidence interval is shown in brackets. Tick marks represent censored patients. medOS, median overall survival; HR, hazard ratio.
See this image and copyright information in PMC

References

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    1. Derosa L, Hellmann MD, Spaziano M. et al. Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer. Ann Oncol 2018; 29(6): 1437–1444. - PMC - PubMed
    1. Huemer F, Rinnerthaler G, Westphal T. et al. Impact of antibiotic treatment on immune-checkpoint blockade efficacy in advanced non-squamous non-small cell lung cancer. Oncotarget 2018; 9(23): 16512–16520. - PMC - PubMed
    1. Metges J, Michaud E, Lagadec DD. et al. Impact of anti-infectious and corticosteroids on immunotherapy: nivolumab and pembrolizumab follow-up in a French study. Ann Oncol 2018; 29(Suppl 8): viii400–viii441.

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