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. 2019 Aug 30;69(6):1071-1078.
doi: 10.1093/cid/ciz060.

Global Review of the Age Distribution of Rotavirus Disease in Children Aged <5 Years Before the Introduction of Rotavirus Vaccination

Mateusz Hasso-Agopsowicz  1   2 , Chandresh Nanji Ladva  3 , Benjamin Lopman  3 , Colin Sanderson  1 , Adam L Cohen  2 , Jacqueline E Tate  4 , Ximena Riveros  2 , Ana Maria Henao-Restrepo  2 , Andrew Clark  1 ; Global Rotavirus Surveillance Network and Rotavirus Age Study Collaborators
Collaborators, Affiliations

Global Review of the Age Distribution of Rotavirus Disease in Children Aged <5 Years Before the Introduction of Rotavirus Vaccination

Mateusz Hasso-Agopsowicz et al. Clin Infect Dis. .

Abstract

We sought datasets with granular age distributions of rotavirus-positive disease presentations among children <5 years of age, before the introduction of rotavirus vaccines. We identified 117 datasets and fit parametric age distributions to each country dataset and mortality stratum. We calculated the median age and the cumulative proportion of rotavirus gastroenteritis events expected to occur at ages between birth and 5.0 years. The median age of rotavirus-positive hospital admissions was 38 weeks (interquartile range [IQR], 25-58 weeks) in countries with very high child mortality and 65 weeks (IQR, 40-107 weeks) in countries with very low or low child mortality. In countries with very high child mortality, 69% of rotavirus-positive admissions in children <5 years of age were in the first year of life, with 3% by 10 weeks, 8% by 15 weeks, and 27% by 26 weeks. This information is critical for assessing the potential benefits of alternative rotavirus vaccination schedules in different countries and for monitoring program impact.

Keywords: age distribution; rotavirus; rotavirus gastroenteritis; vaccine.

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Figures

Figure 1.
Figure 1.
Flowchart of the study selection process and data extraction. Some studies contained multiple datasets. Abbreviations: EIA, enzyme immunoassay; ELISA, enzyme-linked immunosorbent assay; GRSN, Global Rotavirus Surveillance Network; Pre-Vac, prevaccination; Post-Vac, postvaccination; RT-PCR, reverse-transcription polymerase chain reaction.
Figure 2.
Figure 2.
Age distributions of rotavirus-positive hospital admissions by under-5 mortality strata.
Figure 3.
Figure 3.
Estimated and extrapolated prevaccination median age of rotavirus-positive hospital admissions in children aged <5 years, by country. Lighter red represents younger median age and darker red represents older median age. If >1 study was conducted within a country, the median of median ages was used. If no data were available for a country, the median age was extrapolated (indicated by diagonal shading) using the median age of the under-5 mortality stratum. Abbreviations: GRSN, Global Rotavirus Surveillance Network; RVGE, rotavirus gastroenteritis. The map is reprinted with permission from the World Health Organization.
See this image and copyright information in PMC

References

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