Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 May 24;219(12):1989-1993.
doi: 10.1093/infdis/jiz034.

Pneumococcal Colonization in Healthy Adult Research Participants in the Conjugate Vaccine Era, United Kingdom, 2010-2017

Hugh Adler  1   2 , Elissavet Nikolaou  1 , Katherine Gould  3   4 , Jason Hinds  3   4 , Andrea M Collins  1   2   5 , Victoria Connor  1   2 , Caz Hales  1   2 , Helen Hill  1   2 , Angela D Hyder-Wright  1   2   6 , Seher R Zaidi  1   2 , Esther L German  1 , Jenna F Gritzfeld  1 , Elena Mitsi  1 , Sherin Pojar  1 , Stephen B Gordon  1   7 , Adam P Roberts  8 , Jamie Rylance  1   7 , Daniela M Ferreira  1
Affiliations

Pneumococcal Colonization in Healthy Adult Research Participants in the Conjugate Vaccine Era, United Kingdom, 2010-2017

Hugh Adler et al. J Infect Dis. .

Abstract

Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (all were nonsmokers without major comorbidities or contact with children aged <5 years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% of volunteers (52 of 795). Serotype 3 was the commonest serotype (10 of 52 isolates). The majority of the remaining serotypes (35 of 52 isolates) were nonvaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least 1 of 6 antibiotics tested was found in 8 of 52 isolates.

Keywords: Streptococcus pneumoniae; Drug resistance; herd immunity; microbial; nasal washing.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Serotype distribution among subjects colonized with vaccine serotypes (left) or nonvaccine serotypes (right) before (white bars) and after (gray bars) the 5-year anniversary of the introduction of the 13-valent pneumococcal vaccine (PCV13) in the United Kingdom.
See this image and copyright information in PMC

Comment in

References

    1. Yahiaoui RY, den Heijer CDJ, van Bijnen EM, et al. ; APRES Study Team Prevalence and antibiotic resistance of commensal Streptococcus pneumoniae in nine European countries. Future Microbiol 2016; 11:737–44. - PubMed
    1. Hammitt LL, Bruden DL, Butler JC, et al. Indirect effect of conjugate vaccine on adult carriage of Streptococcus pneumoniae: an explanation of trends in invasive pneumococcal disease. J Infect Dis 2006; 193:1487–94. - PubMed
    1. Ladhani SN, Collins S, Djennad A, et al. Rapid increase in non-vaccine serotypes causing invasive pneumococcal disease in England and Wales, 2000-17: a prospective national observational cohort study. Lancet Infect Dis 2018; 18:441–51. - PubMed
    1. Southern J, Andrews N, Sandu P, et al. Pneumococcal carriage in children and their household contacts six years after introduction of the 13-valent pneumococcal conjugate vaccine in England. PLoS One 2018; 13:e0195799. - PMC - PubMed
    1. European Centre for Disease Prevention and Control T. Antimicrobial resistance surveillance in Europe 2016. Stockholm: Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net), 2017.

Publication types