Asthma and Corticosteroid Responses in Childhood and Adult Asthma

doi:10.1016/j.ccm.2018.10.010

Review

. 2019 Mar;40(1):163-177.

doi: 10.1016/j.ccm.2018.10.010.

Asthma and Corticosteroid Responses in Childhood and Adult Asthma

Amira Ali Ramadan¹, Jonathan M Gaffin², Elliot Israel³, Wanda Phipatanakul⁴

Affiliations

¹ Division of Allergy and Immunology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Beth Israel Deaconess Center, Cardiovascular institute, 330 Brookline Avenue, Boston, MA 02215, USA.
² Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA.
³ Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Brigham and Women's Hospital, 15 Francis Street, Boston, MA 02115, USA.
⁴ Division of Allergy and Immunology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: Wanda.Phipatanakul@childrens.harvard.edu.

PMID: 30691710
PMCID: PMC6355159
DOI: 10.1016/j.ccm.2018.10.010

Review

Asthma and Corticosteroid Responses in Childhood and Adult Asthma

Amira Ali Ramadan et al. Clin Chest Med. 2019 Mar.

. 2019 Mar;40(1):163-177.

doi: 10.1016/j.ccm.2018.10.010.

Authors

Amira Ali Ramadan¹, Jonathan M Gaffin², Elliot Israel³, Wanda Phipatanakul⁴

Affiliations

¹ Division of Allergy and Immunology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Beth Israel Deaconess Center, Cardiovascular institute, 330 Brookline Avenue, Boston, MA 02215, USA.
² Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA.
³ Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Brigham and Women's Hospital, 15 Francis Street, Boston, MA 02115, USA.
⁴ Division of Allergy and Immunology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: Wanda.Phipatanakul@childrens.harvard.edu.

PMID: 30691710
PMCID: PMC6355159
DOI: 10.1016/j.ccm.2018.10.010

Abstract

Corticosteroids are the most effective treatment for asthma; inhaled corticosteroids (ICSs) are the first-line treatment for children and adults with persistent symptoms. ICSs are associated with significant improvements in lung function. The anti-inflammatory effects of corticosteroids are mediated by both genomic and nongenomic factors. Variation in the response to corticosteroids has been observed. Patient characteristics, biomarkers, and genetic features may be used to predict response to ICSs. The existence of multiple mechanisms underlying glucocorticoid insensitivity raises the possibility that this might indeed reflect different diseases with a common phenotype.

Keywords: Adult asthma; Childhood asthma; Corticosteroid resistance; Corticosteroid response; Inhaled corticosteroids.

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References

1. Global strategy for asthma management and prevention [Internet]. [Updated 2017; cited 2017 Nov Sep 1]. Available from: Available from: http://ginasthma.org/gina-reports/
1. CDC. NHIS Data. Table 3-1. 2015;www.cdc.gov/asthma/nhis/2015/table3-1.htm.
1. Lougheed MD, Lemiere C, Ducharme FM, Licskai C, Dell SD, Rowe BH, et al. Canadian Thoracic Society 2012 guideline update: Diagnosis and management of asthma in preschoolers, children and adults: Executive summary. Can Respir J. 2012;19(6):e81–8. - PMC - PubMed
1. Barnes PJ. Inhaled Corticosteroids. Pharmaceuticals (Basel). 2010;3(3):514–40. - PMC - PubMed
1. Fergeson JE, Patel SS, Lockey RF. Acute asthma, prognosis, and treatment. J Allergy Clin Immunol. 2017;139(2):438–47. - PubMed

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[1] Global strategy for asthma management and prevention [Internet]. [Updated 2017; cited 2017 Nov Sep 1]. Available from: Available from: http://ginasthma.org/gina-reports/

[2] Global strategy for asthma management and prevention [Internet]. [Updated 2017; cited 2017 Nov Sep 1]. Available from: Available from: http://ginasthma.org/gina-reports/

[3] CDC. NHIS Data. Table 3-1. 2015;www.cdc.gov/asthma/nhis/2015/table3-1.htm.

[4] CDC. NHIS Data. Table 3-1. 2015;www.cdc.gov/asthma/nhis/2015/table3-1.htm.

[5] Lougheed MD, Lemiere C, Ducharme FM, Licskai C, Dell SD, Rowe BH, et al. Canadian Thoracic Society 2012 guideline update: Diagnosis and management of asthma in preschoolers, children and adults: Executive summary. Can Respir J. 2012;19(6):e81–8. - PMC - PubMed

[6] Lougheed MD, Lemiere C, Ducharme FM, Licskai C, Dell SD, Rowe BH, et al. Canadian Thoracic Society 2012 guideline update: Diagnosis and management of asthma in preschoolers, children and adults: Executive summary. Can Respir J. 2012;19(6):e81–8. - PMC - PubMed

[7] Barnes PJ. Inhaled Corticosteroids. Pharmaceuticals (Basel). 2010;3(3):514–40. - PMC - PubMed

[8] Barnes PJ. Inhaled Corticosteroids. Pharmaceuticals (Basel). 2010;3(3):514–40. - PMC - PubMed

[9] Fergeson JE, Patel SS, Lockey RF. Acute asthma, prognosis, and treatment. J Allergy Clin Immunol. 2017;139(2):438–47. - PubMed

[10] Fergeson JE, Patel SS, Lockey RF. Acute asthma, prognosis, and treatment. J Allergy Clin Immunol. 2017;139(2):438–47. - PubMed

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Asthma and Corticosteroid Responses in Childhood and Adult Asthma

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Asthma and Corticosteroid Responses in Childhood and Adult Asthma

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