Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar;40(1):29-50.
doi: 10.1016/j.ccm.2018.10.014.

Proinflammatory Pathways in the Pathogenesis of Asthma

R Stokes Peebles Jr  1 , Mark A Aronica  2
Affiliations
Review

Proinflammatory Pathways in the Pathogenesis of Asthma

R Stokes Peebles Jr et al. Clin Chest Med. 2019 Mar.

Abstract

There are multiple proinflammatory pathways in the pathogenesis of asthma. These include both innate and adaptive inflammation, in addition to inflammatory and physiologic responses mediated by eicosanoids. An important component of the innate allergic immune response is ILC2 activated by interleukin (IL)-33, thymic stromal lymphopoietin, and IL-25 to produce IL-5 and IL-13. In terms of the adaptive T-lymphocyte immunity, CD4+ Th2 and IL-17-producing cells are critical in the inflammatory responses in asthma. Last, eicosanoids involved in asthma pathogenesis include prostaglandin D2 and the cysteinyl leukotrienes that promote smooth muscle constriction and inflammation that propagate allergic responses.

Keywords: Adaptive; Asthma; Innate; Prostaglandin leukotriene.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:
Pathway of innate allergic inflammation
Figure 2:
Figure 2:
Pathway of adaptive allergic inflammation
Figure 3:
Figure 3:
Pathway of Th17 mediated inflammatory responses
Figure 4:
Figure 4:
Metabolism of Arachidonic Acid through the cyclooxygenase (COX) and 5-lipoxygenase (5-LO) pathways
See this image and copyright information in PMC

References

    1. National Heart L, and Blood Institute. Guidelines for the diagnosis and management of asthma (EPR-3). 2007
    1. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986;136(7):2348–2357. - PubMed
    1. Durbin JE, Johnson TR, Durbin RK, et al. The role of IFN in respiratory syncytial virus pathogenesis. J Immunol. 2002;168(6):2944–2952. - PubMed
    1. Neill DR, Wong SH, Bellosi A, et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 2010;464(7293):1367–1370. - PMC - PubMed
    1. Price AE, Liang HE, Sullivan BM, et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A. 2010;107(25):11489–11494. - PMC - PubMed

Publication types