Can Mendelian Randomization Shift into Reverse Gear?

Michael V Holmes^{1

2

3

4}, George Davey Smith^{4

5

6}

Affiliations

¹ Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK; michael.holmes@ndph.ox.ac.uk.
² Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
³ National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK.
⁴ Medical Research Council Integrative Epidemiology Unit, University of Bristol, UK.
⁵ Population Health Sciences, University of Bristol, Bristol, UK.
⁶ National Institute for Health Research Bristol Biomedical Research Centre, Bristol, UK.

Editorial

Michael V Holmes et al. Clin Chem. 2019 Mar.

. 2019 Mar;65(3):363-366.

doi: 10.1373/clinchem.2018.296806. Epub 2019 Jan 28.

Michael V Holmes^{1

2

3

4}, George Davey Smith^{4

5

6}

¹ Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK; michael.holmes@ndph.ox.ac.uk.
² Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
³ National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK.
⁴ Medical Research Council Integrative Epidemiology Unit, University of Bristol, UK.
⁵ Population Health Sciences, University of Bristol, Bristol, UK.
⁶ National Institute for Health Research Bristol Biomedical Research Centre, Bristol, UK.

No abstract available

Comment on

A Mendelian Randomization-Based Approach to Identify Early and Sensitive Diagnostic Biomarkers of Disease.
Mohammadi-Shemirani P, Sjaarda J, Gerstein HC, Treleaven DJ, Walsh M, Mann JF, McQueen MJ, Hess S, Paré G. Mohammadi-Shemirani P, et al. Clin Chem. 2019 Mar;65(3):427-436. doi: 10.1373/clinchem.2018.291104. Epub 2018 Oct 18. Clin Chem. 2019. PMID: 30337280