Oncogenic AKTivation by methylation
- PMID: 30692624
- DOI: 10.1038/s41556-019-0275-8
Oncogenic AKTivation by methylation
Comment on
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AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.Nat Cell Biol. 2019 Feb;21(2):226-237. doi: 10.1038/s41556-018-0261-6. Epub 2019 Jan 28. Nat Cell Biol. 2019. PMID: 30692625 Free PMC article.
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SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis.Nat Cell Biol. 2019 Feb;21(2):214-225. doi: 10.1038/s41556-018-0266-1. Epub 2019 Jan 28. Nat Cell Biol. 2019. PMID: 30692626 Free PMC article.
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