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Review
. 2018 Nov 21;10(11):e3620.
doi: 10.7759/cureus.3620.

Kidney Carcinoma Ovarian Metastasis: Review of the Literature

Nektarios Koufopoulos  1 , Despoina Nasi  2 , Foteini Antoniadou  1 , Stefania Kokkali  2 , Stamatios Theocharis  3
Affiliations
Review

Kidney Carcinoma Ovarian Metastasis: Review of the Literature

Nektarios Koufopoulos et al. Cureus. .

Abstract

Ovarian metastasis is common with secondary tumors representing up to 15% of ovarian neoplasms. The malignancies most commonly involving the ovaries are carcinomas of the stomach, colon, breast, endocervix, endometrium, and lymphoma. Secondary ovarian involvement by kidney carcinoma occurs very rarely and is usually associated with widespread dissemination. We conducted a review of kidney carcinoma with ovarian metastasis in the literature using the keywords clear cell renal cell carcinoma, papillary renal cell carcinoma, chromophobe renal cell carcinoma collecting duct carcinoma, and ovarian metastasis on Google Scholar and PubMed indices in April 2018, including a case diagnosed in our department. To date, 30 articles presenting 41 cases of kidney carcinoma with ovarian metastasis are reported in the literature. All reviewed cases were analyzed for diagnosis, surgical and systemic therapy, and outcome. Diagnosis may sometimes be challenging, requiring appropriate immunohistochemical markers in difficult cases. A combination of surgery and adjuvant therapy offers significant benefit in disease control or palliation of symptoms. Due to inconsistency in the reported data, further studies are needed to make safe conclusions regarding survival.

Keywords: chromophobe renal cell carcinoma; clear cell renal cell carcinoma; collecting duct carcinoma; metastasis; ovary; papillary renal cell carcinoma.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. (a) ccRCC tumor cells with moderately atypical nuclei lacking significant pleomorphism (H&E x 100). (b) On higher power magnification, a prominent, thin-walled vascular network is characteristic of ccRCC (H&E x 200).
ccRCC: clear cell renal cell carcinoma, H&E: hematoxylin and eosin
Figure 2
Figure 2. (a) CD-10 is usually diffusely positive in ccRCC cells (CD-10 x 200). (b) Tumor cells showing positive staining for RCCma (RCCma x 200)
ccRCC: clear cell renal cell carcinoma, RCCma: renal cell carcinoma marker
See this image and copyright information in PMC

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