[Effect of 5-hydroxytryptophan and serotonin antagonists on the functional state of the adrenal cortex]

Abstract

The effect of 5-oxytryptophan, injected singly and in combination with the serotonin antagonists (novocain, atropine and bigumal) on the ascorbic acid level in the adrenal cortex and the eosinophilic content in the peripheral blood of white rats was studied. It was ascertained that 5-oxytryptophan reduced significantly the amount of ascorbic acid in the adrenal cortex and produced eosinopenia. Novocain, atropine and bigumal did not exert a similar effect. A combined injection of 5-oxytryptophan together with the mentioned antagonists of serotonin prevented eosinopenia evoked by 5-oxytryptophan. At the same time, the tested antagonists of serotonin did not change the effect of 5-oxytryptophan on the level of ascorbic acid in the adrenal cortex.