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Review
. 2018 May 25;47(5):493-498.
doi: 10.3785/j.issn.1008-9292.2018.10.08.

[Roles of astrocytes in cerebral infarction and related therapeutic strategies]

[Article in Chinese]
Jianyu Ye  1 , Ziyu Sun  1 , Weiwei Hu  2
Affiliations
Review

[Roles of astrocytes in cerebral infarction and related therapeutic strategies]

[Article in Chinese]
Jianyu Ye et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. .

Abstract
in English, Chinese

Astrocytes are the most abundant cells in the central nervous system and play significant roles in normal brain. With cerebral infarction, astrocytes are activated as reactive astrocytes and form glial scars, which play an essential part in brain injury. According to their roles in neuroprotection after cerebral infarction, regulation of scar formation, nerve regeneration, maintenance of blood-brain barrier, promotion of angiogenesis and immune response, scholars have proposed a variety of therapeutic strategies based on targeting astrocytes. This article reviews the research progress on the changes in astrocyte signaling pathways before and after cerebral infarction and the related therapeutic strategies.

星形胶质细胞是中枢神经系统中最丰富的细胞，在大脑正常生理过程中扮演重要角色。脑梗死发生后，星形胶质细胞激活成为反应性星形胶质细胞，并形成胶质瘢痕，在脑损伤过程中发挥重要作用。根据其在脑梗死后神经保护、调节瘢痕形成、神经再生、维持血脑屏障和促进血管生成、调节免疫应答等方面的作用，学者们提出了靶向星形胶质细胞的多种治疗策略。本文就反应性星形胶质细胞在脑梗死后发挥的积极作用以及相应的治疗策略作一综述。

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