TERT gene: its function and dysregulation in cancer

Andrew J Colebatch¹, Alexander Dobrovic^{2

3

4

5}, Wendy A Cooper^{6

7

8}

Affiliations

¹ Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia andrew.colebatch@health.nsw.gov.au.
² Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia.
³ School of Cancer Medicine and Molecular Cancer Prevention Program, La Trobe University, Melbourne, Victoria, Australia.
⁴ Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.
⁵ Department of Surgery, The University of Melbourne, Heidelberg, Victoria, Australia.
⁶ Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.
⁷ Sydney Medical School, The University of Sydney, Camperdown, New South Wales, Australia.
⁸ School of Medicine, Western Sydney University, Sydney, New South Wales, Australia.

PMID: 30696697
DOI: 10.1136/jclinpath-2018-205653

Review

TERT gene: its function and dysregulation in cancer

Andrew J Colebatch et al. J Clin Pathol. 2019 Apr.

. 2019 Apr;72(4):281-284.

doi: 10.1136/jclinpath-2018-205653. Epub 2019 Jan 29.

Authors

Andrew J Colebatch¹, Alexander Dobrovic^{2

3

4

5}, Wendy A Cooper^{6

7

8}

Affiliations

¹ Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia andrew.colebatch@health.nsw.gov.au.
² Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia.
³ School of Cancer Medicine and Molecular Cancer Prevention Program, La Trobe University, Melbourne, Victoria, Australia.
⁴ Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.
⁵ Department of Surgery, The University of Melbourne, Heidelberg, Victoria, Australia.
⁶ Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.
⁷ Sydney Medical School, The University of Sydney, Camperdown, New South Wales, Australia.
⁸ School of Medicine, Western Sydney University, Sydney, New South Wales, Australia.

PMID: 30696697
DOI: 10.1136/jclinpath-2018-205653

Abstract

In this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations across a range of cancers is discussed. The molecular mechanism activated by TERT promoter mutations is outlined. Finally, the timing of TERT promoter mutations during carcinogenesis is reviewed in the context of their potential utility as clinical biomarkers of malignant transformation.

Keywords: cancer; cancer genetics; cancer research.

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Conflict of interest statement

Competing interests: None declared.

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TERT gene: its function and dysregulation in cancer

Affiliations

TERT gene: its function and dysregulation in cancer

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources