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Review
. 2018 Nov-Dec;23(6):432-446.
doi: 10.5863/1551-6776-23.6.432.

An Introduction to Pharmacotherapy for Inborn Errors of Metabolism

Aaron A Harthan
Review

An Introduction to Pharmacotherapy for Inborn Errors of Metabolism

Aaron A Harthan. J Pediatr Pharmacol Ther. 2018 Nov-Dec.

Abstract

Inborn errors of metabolism comprise a wide array of diseases and complications in the pediatric patient. The rarity of these disorders limits the ability to conduct and review robust literature regarding the disease states, mechanisms of dysfunction, treatments, and outcomes. Often, treatment plans will be based on the pathophysiology associated with the disorder and theoretical agents that may be involved in the metabolic process. Medication therapies usually consist of natural or herbal products. Established efficacious pediatric doses for these products are difficult to find in tertiary resources, and adverse effects are routinely limited to single case reports. This review article attempts to summarize some of the more common inborn errors of metabolism in a manner that is applicable to pharmacists who will provide care for these patients.

Keywords: dietary supplements; drug therapy; inborn errors; metabolism; review.

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Conflict of interest statement

Disclosure The author declares no conflicts or financial interest in any product or service mentioned in the manuscript, including grants, equipment, medications, employment, gifts, and honoraria.

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