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Case Reports
. 2019 Oct;44(7):e238-e239.
doi: 10.1111/ced.13876. Epub 2019 Jan 29.

Inherited desmoplastic trichoepitheliomas

M-L Lovgren  1 , N Rajan  2 , S Joss  3 , L Melly  4 , M Porter  1
Affiliations
Case Reports

Inherited desmoplastic trichoepitheliomas

M-L Lovgren et al. Clin Exp Dermatol. 2019 Oct.
No abstract available

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Figures

Figure 1
Figure 1
(a) The proband had a central forehead lesion (black arrow) demonstrating an ill‐defined skin‐coloured lesion 3 mm in size, with milia‐like cysts. (b) Pedigree demonstrating a family history of desmoplastic trichoepitheliomas and a basal cell carcinoma; black arrow indicates the proband.
Figure 2
Figure 2
(a) Incisional biopsy from the proband's sister's right mandible demonstrating small keratocysts and thin strands of basaloid cells in the superficial dermis with a single focus of perineural invasion and no subcutis invasion. Immunocytochemistry for CK20, epidermal membrane antigen and carcinoembryonic antigen was negative. No retraction artefact or peripheral palisading was seen, and BerEP4 was only focally positive. (b) Perineural invasion in the right mandibular lesion (black arrow). Haematoxylin and eosin, original magnification (a) × 100; (b) × 200.
See this image and copyright information in PMC

References

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    1. Wang Q, Ghmire D, Wang J et al Desmoplastic trichoepithelioma: a clinicopathological study of three cases and a review of the literature. Oncol Lett 2015; 10: 2468–76. - PMC - PubMed
    1. Shapiro PE. Re: Familial desmoplastic trichoepithelioma. Int J Dermatol 2007; 46: 1320–1. - PubMed
    1. Shapiro PE, Kopf AW. Familial multiple desmoplastic trichoepitheliomas. Arch Dermatol 1991; 127: 83–7. - PubMed
    1. Abbate M, Zeitouni NC, Seyler M et al Clinical course, risk factors, and treatment of microcystic adnexal carcinoma: a short series report. Dermatol Surg Off Publ Am Soc Dermatol Surg Al 2003; 29: 1035–8. - PubMed

Substances

Supplementary concepts