Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jan 30:20:e7.
doi: 10.1017/erm.2018.7.

Structure, regulation and related diseases of the actin-binding protein gelsolin

Jessica Feldt  1 , Martin Schicht  1 , Fabian Garreis  1 , Jessica Welss  1 , Ulrich W Schneider  2 , Friedrich Paulsen  1
Affiliations
Review

Structure, regulation and related diseases of the actin-binding protein gelsolin

Jessica Feldt et al. Expert Rev Mol Med. .

Abstract

Gelsolin (GSN), one of the most abundant actin-binding proteins, is involved in cell motility, shape and metabolism. As a member of the GSN superfamily, GSN is a highly structured protein in eukaryotic cells that can be regulated by calcium concentration, intracellular pH, temperature and phosphatidylinositol-4,5-bisphosphate. GSN plays an important role in cellular mechanisms as well as in different cellular interactions. Because of its participation in immunologic processes and its interaction with different cells of the immune system, GSN is a potential candidate for various therapeutic applications. In this review, we summarise the structure of GSN as well as its regulating and functional roles, focusing on distinct diseases such as Alzheimer's disease, rheumatoid arthritis and cancer. A short overview of GSN as a therapeutic target in today's medicine is also provided.

Keywords: Actin-binding protein; diseases; gelsolin; regulation; structure.

PubMed Disclaimer

LinkOut - more resources