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. 2019 May 1;154(5):413-420.
doi: 10.1001/jamasurg.2018.5248.

Association of Surgical Intervention for Adhesive Small-Bowel Obstruction With the Risk of Recurrence

Ramy Behman  1 , Avery B Nathens  1   2   3 , Stephanie Mason  1 , James P Byrne  1 , Nicole Look Hong  1   2   3 , Petros Pechlivanoglou  3   4 , Paul Karanicolas  1   2   3
Affiliations

Association of Surgical Intervention for Adhesive Small-Bowel Obstruction With the Risk of Recurrence

Ramy Behman et al. JAMA Surg. .

Abstract

Importance: Adhesive small-bowel obstruction (aSBO) is a potentially chronic, recurring surgical illness. Although guidelines suggest trials of nonoperative management, the long-term association of this approach with recurrence is poorly understood.

Objective: To compare the incidence of recurrence of aSBO in patients undergoing operative management at their first admission compared with nonoperative management.

Design, setting, and participants: This longitudinal, propensity-matched, retrospective cohort study used health administrative data for the province of Ontario, Canada, for patients treated from April 1, 2005, through March 31, 2014. The study population included adults aged 18 to 80 years who were admitted for their first episode of aSBO. Patients with nonadhesive causes of SBO were excluded. A total of 27 904 patients were included and matched 1:1 by their propensity to undergo surgery. Factors used to calculate propensity included patient age, sex, comorbidity burden, socioeconomic status, and rurality of home residence. Data were analyzed from September 10, 2017, through October 4, 2018.

Exposures: Operative vs nonoperative management for aSBO.

Main outcomes and measures: The primary outcome was the rate of recurrence of aSBO among those with operative vs nonoperative management. Time-to-event analyses were used to estimate hazard ratios of recurrence while accounting for the competing risk of death.

Results: Of 27 904 patients admitted with their first episode of aSBO, 6186 (22.2%) underwent operative management. Mean (SD) patient age was 61.2 (13.6) years, and 51.1% (14 228 of 27 904) were female. Patients undergoing operative management were younger (mean [SD] age, 60.2 [14.3] vs 61.5 [13.4] years) with fewer comorbidities (low burden, 382 [6.2%] vs 912 [4.2%]). After matching, those with operative management had a lower risk of recurrence (13.0% vs 21.3%; hazard ratio, 0.62; 95% CI, 0.56-0.68; P < .001). The 5-year probability of experiencing another recurrence increased with each episode until surgical intervention, at which point the risk of subsequent recurrence decreased by approximately 50%.

Conclusions and relevance: According to this study, operative management of the first episode of aSBO is associated with significantly reduced risk of recurrence. Guidelines advocating trials of nonoperative management for aSBO may assume that surgery increases the risk of recurrence putatively through the formation of additional adhesions. The long-term risk of recurrence of aSBO should be considered in the management of this patient population.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure 1.
Figure 1.. Patient Eligibility Flowchart
IBD indicates inflammatory bowel disease; RT, radiotherapy (abdominal or pelvic); SBO, small-bowel obstruction.
Figure 2.
Figure 2.. Probability of Additional Recurrences as a Function of the Number of Previous Episodes
Error bars indicate 95% CI.
Figure 3.
Figure 3.. Mean Time Between Episodes of Adhesive Small-Bowel Obstruction as a Function of the Number of Previous Episodes
Error bars indicate 95% CI.
Figure 4.
Figure 4.. Probability of Recurrence by Management Strategy
Data are stratified by nonoperative management at all previous episodes (A) or include all patients regardless of previous management (B).
See this image and copyright information in PMC

Comment in

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