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. 2019 Jan 30;19(1):50.
doi: 10.1186/s12888-019-2025-7.

Clinical guidelines for the management of depression with specific comorbid psychiatric conditions French recommendations from experts (the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental)

D Bennabi  1 , A Yrondi  2 , T Charpeaud  3 , J-B Genty  4 , S Destouches  4 , S Lancrenon  4 , N Allaili  5 , F Bellivier  5 , T Bougerol  6 , V Camus  7 , O Doumy  8 , J-M Dorey  9   10   11 , F Haesebaert  12 , J Holtzmann  6 , C Lançon  13 , M Lefebvre  12 , F Moliere  14 , I Nieto  5 , C Rabu  15 , R Richieri  13 , L Schmitt  2 , F Stephan  16 , G Vaiva  17 , M Walter  16 , M Leboyer  15 , W El-Hage  7 , B Aouizerate  8 , E Haffen  18 , P-M Llorca  3 , P Courtet  14
Affiliations

Clinical guidelines for the management of depression with specific comorbid psychiatric conditions French recommendations from experts (the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental)

D Bennabi et al. BMC Psychiatry. .

Abstract

Background: Recommendations for pharmacological treatments of major depression with specific comorbid psychiatric conditions are lacking.

Method: The French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental developed expert consensus guidelines for the management of depression based on the RAND/UCLA Appropriatneness Method. Recommendations for lines of treatment are provided by the scientific committee after data analysis and interpretation of the results of a survey of 36 psychiatrist experts in the field of major depression and its treatments.

Results: The expert guidelines combine scientific evidence and expert clinician's opinion to produce recommendations for major depression with comorbid anxiety disorders, personality disorders or substance use disorders and in geriatric depression.

Conclusion: These guidelines provide direction addressing common clinical dilemmas that arise in the pharmacologic treatment of major depression with comorbid psychiatric conditions.

Keywords: Anxiety disorders; Elderly; Major depressive disorder; Pharmacotherapy; Substance use disorders.

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Conflict of interest statement

Ethics approval and consent to participate

Written informed consents were obtained from participating medical experts.

Consent for publication

Not Applicable.

Competing interests

No financial support was received for this study and there are no potential conflicts of interest to declare. Regarding financial support unrelated to the present article, we disclose that NA has benefited from financial support for conferences and has been scientific responsible and experimenter for preclinical studies from Servier laboratories. BA has perceived honoraria to communicate at conferences from Laboratories AstraZeneca, Lundbeck and Janssen. VC has benefited from honoraria and financial support for conferences from Laboratories Otsuka, Novartis, Lundbeck, Servier, Janssen and has been experimenter for studies from Janssen and Lilly.TC has benefited from honoraria and financial support for conferences from Laboratories AstraZeneca, Janssen and Lundbeck and has been experimenter for studies from Janssen. PC has benefited from honoraria and financial support for conferences, training action and for participation in experts groups from Servier and Janssen. OD has benefited from honoraria and financial support for conferences from Lilly, AstraZeneca, Servier, Lundbeck and Janssen. J-MD has benefited from honoraria for conferences from Lundbeck. WE has benefited from honoraria and financial support for conferences, training action and for participation in experts groups from Lundbeck, Janssen, and Otsuka. FH has benefited from financial support for conferences, grant from BMS and AstraZeneca, training grant from Servier and a research grant from « Fonds de Recherche du Québec - Nature et Technologie (#200123) » and has been experimenter for studies from EH has benefited from honoraria and financial support for conferences, training action and for participation in experts groups from AstraZeneca, BMS, Euthérapie Servier, Janssen, Livanova, Lundbeck, Otsuka and has been experimenter for studies from Janssen. JH has benefited from honoraria and financial support for conferences from Lundbeck, Servier has been experimenter for studies from Janssen. CL has benefited from honoraria and financial support for training action from Lundbeck. P-ML has benefited from honoraria and financial support for conferences, training action and for participation in experts groups from Janssen, EISAI, Lundbeck, Otsuka, Allergan. FM has benefited from honoraria for conferences from Lundbeck, Otsuka. GV has benefited from honoraria and financial support for conferences, training action and for participation in experts groups from Janssen and Otsuka. AY has benefited from honoraria and financial support for conferences from Lundbeck, Janssen, AstraZeneca; for participation in experts groups from Lundbeck and has participated in reseach studies from Lundbeck.

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References

    1. Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the global burden of disease study 2010. Lancet. 2012;380(9859):2197–2223. doi: 10.1016/S0140-6736(12)61689-4. - DOI - PubMed
    1. Gilmer WS, Trivedi MH, Rush AJ, Wisniewski SR, Luther J, Howland RH, et al. Factors associated with chronic depressive episodes: a preliminary report from the STAR-D project. Acta Psychiatr Scand. 2005;112(6):425–433. doi: 10.1111/j.1600-0447.2005.00633.x. - DOI - PubMed
    1. Murphy JA, Byrne GJ. Prevalence and correlates of the proposed DSM-5 diagnosis of chronic depressive disorder. J Affect Disord. 2012;139(2):172–180. doi: 10.1016/j.jad.2012.01.033. - DOI - PubMed
    1. Rush AJ, Zimmerman M, Wisniewski SR, Fava M, Hollon SD, Warden D, et al. Comorbid psychiatric disorders in depressed outpatients: demographic and clinical features. J Affect Disord. 2005;87(1):43–55. doi: 10.1016/j.jad.2005.03.005. - DOI - PubMed
    1. Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163(11):1905–1917. doi: 10.1176/ajp.2006.163.11.1905. - DOI - PubMed

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