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Review
. 2019 Mar 21;93(7):e01003-18.
doi: 10.1128/JVI.01003-18. Print 2019 Apr 1.

An Emerging Issue in Oncogenic Virology: the Role of Beta Human Papillomavirus Types in the Development of Cutaneous Squamous Cell Carcinoma

Dana E Rollison  1 , Daniele Viarisio  2 , Rossybelle P Amorrortu  1 , Tarik Gheit  3 , Massimo Tommasino  4
Affiliations
Review

An Emerging Issue in Oncogenic Virology: the Role of Beta Human Papillomavirus Types in the Development of Cutaneous Squamous Cell Carcinoma

Dana E Rollison et al. J Virol. .

Abstract

Evidence suggests that beta human papillomaviruses (HPVs), together with ultraviolet radiation, contribute to the development of cutaneous squamous cell carcinoma. Beta HPVs appear to be not the main drivers of carcinogenesis but rather facilitators of the accumulation of ultraviolet-induced DNA mutations. Beta HPVs are promoters of skin carcinogenesis, although they are dispensable for the maintenance of the malignant phenotype. Therefore, beta HPV represents a target for skin cancer prevention, especially in high-risk populations.

Keywords: UV radiation; human papillomavirus; skin cancer.

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Figures

FIG 1
FIG 1
Working model for cooperation between beta HPV types and UV radiation in promoting cSCC.
See this image and copyright information in PMC

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