Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar 21;93(7):e01003-18.
doi: 10.1128/JVI.01003-18. Print 2019 Apr 1.

An Emerging Issue in Oncogenic Virology: the Role of Beta Human Papillomavirus Types in the Development of Cutaneous Squamous Cell Carcinoma

Dana E Rollison  1 , Daniele Viarisio  2 , Rossybelle P Amorrortu  1 , Tarik Gheit  3 , Massimo Tommasino  4
Affiliations
Review

An Emerging Issue in Oncogenic Virology: the Role of Beta Human Papillomavirus Types in the Development of Cutaneous Squamous Cell Carcinoma

Dana E Rollison et al. J Virol. .

Abstract

Evidence suggests that beta human papillomaviruses (HPVs), together with ultraviolet radiation, contribute to the development of cutaneous squamous cell carcinoma. Beta HPVs appear to be not the main drivers of carcinogenesis but rather facilitators of the accumulation of ultraviolet-induced DNA mutations. Beta HPVs are promoters of skin carcinogenesis, although they are dispensable for the maintenance of the malignant phenotype. Therefore, beta HPV represents a target for skin cancer prevention, especially in high-risk populations.

Keywords: UV radiation; human papillomavirus; skin cancer.

PubMed Disclaimer

Figures

FIG 1
FIG 1
Working model for cooperation between beta HPV types and UV radiation in promoting cSCC.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Van Doorslaer K, Li Z, Xirasagar S, Maes P, Kaminsky D, Liou D, Sun Q, Kaur R, Huyen Y, McBride AA. 2017. The Papillomavirus Episteme: a major update to the papillomavirus sequence database. Nucleic Acids Res 45:D499–D506. doi:10.1093/nar/gkw879. - DOI - PMC - PubMed
    1. Van Doorslaer K, Chen Z, Bernard HU, Chan PKS, DeSalle R, Dillner J, Forslund O, Haga T, McBride AA, Villa LL, Burk RD, ICTV Report Consortium . 2018. ICTV virus taxonomy profile: Papillomaviridae. J Gen Virol 99:989–990. doi:10.1099/jgv.0.001105. - DOI - PMC - PubMed
    1. Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V, WHO International Agency for Research on Cancer Monograph Working Group . 2009. A review of human carcinogens–part B: biological agents. Lancet Oncol 10:321–322. doi:10.1016/S1470-2045(09)70096-8. - DOI - PubMed
    1. Tommasino M. 2014. The human papillomavirus family and its role in carcinogenesis. Semin Cancer Biol 26:13–21. doi:10.1016/j.semcancer.2013.11.002. - DOI - PubMed
    1. Butz K, Ristriani T, Hengstermann A, Denk C, Scheffner M, Hoppe-Seyler F. 2003. siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells. Oncogene 22:5938–5945. doi:10.1038/sj.onc.1206894. - DOI - PubMed

Publication types