Clinical characteristics and prognostic analysis of multiple primary malignant neoplasms in patients with lung cancer
- PMID: 30700800
- DOI: 10.1038/s41417-019-0084-z
Clinical characteristics and prognostic analysis of multiple primary malignant neoplasms in patients with lung cancer
Abstract
Retrospective analysis of data from 14,528 lung cancer patients with multiple primary malignant neoplasm (MPMN) revealed that 2.5% (364/14,528) were MPMN cases and 96.2% (350/364) were diagnosed with two primary malignancies, 3.6% (13/364) with three primary malignancies, and 0.3% (1/364) with four primary malignancies. Among 350 lung cancer patients diagnosed with two primary malignancies, 26.6% (93/350) had lung cancer diagnosed first (LCF) and 73.4% (257/350) had other cancers diagnosed initially (OCF), whereas synchronous MPMN (SMPMN) accounted for 21.1% (74/350) and metachronous MPMN (MMPMN) accounted for 78.9% (276/350) of the cases. Detection of first primary neoplasms were at an early stage for LCF patients and the age of the first lung cancer diagnosis was 59.3 years vs. 55.4 years in the OCF group (P = 0.008), whereas the onset age of second primary neoplasm diagnosis was similar in both groups (62.5 and 61.6 years, P = 0.544). Median survival times of MMPMN and SMPMN patients in the LCF group were 6.83 and 2.42 years and in the OCF group 8.67 years and 2.25 years, respectively. Multivariate analysis showed that SMPMN, LCF and the age of the primary cancer diagnosed first ( ≥ 60 years) and NSCL staging > II were significant independent factors for inferior prognosis of patients.
References
-
- Chen W, Zheng R, Zeng H, Zhang S. Epidemiology of lung cancer in China. Thorac Cancer. 2015;6:209–15. - DOI
-
- Fan H, Shao ZY, Xiao YY, Xie ZH, Chen W, Xie H, et al. Incidence and survival of non-small cell lung cancer in Shanghai: a population-based cohort study. BMJ Open. 2015;5:e009419. - DOI
-
- Levi F, Randimbison L, Rafael BM, Manuela MC, La Vecchia C. Second primary cancers in the Vaud and Neuchatel Cancer Registries. Eur J Cancer Prev. 2015;24:150–4. - DOI
-
- Koubkova L, Hrstka R, Dobes P, Vojtesek B, Vyzula R. Second primary cancers—causes, incidence and the future. Klin Onkol. 2014;27:11–7. - DOI
-
- Tabuchi T, Ito Y, Ioka A, Miyashiro I, Tsukuma H. Incidence of metachronous second primary cancers in Osaka, Japan: update of analyses using population-based cancer registry data. Cancer Sci. 2012;103:1111–20. - DOI
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials