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Observational Study
. 2018 Feb 15;90(2):35-42.
doi: 10.26442/terarkh201890235-42.

European Registry on the management of Helicobacter pylori infection (Hp-EuReg): analysis of 2360 patients receiving first-line therapy in Russia

D S Bordin  1   2 , Yu V Embutnieks  1 , L G Vologzhanina  3 , T A Il'chishina  4 , I N Voinovan  1 , A S Sarsenbaeva  5 , S A Alekseenko  6 , O V Zaitsev  7 , R A Abdulkhakov  8 , M F Osipenko  9 , M A Livzan  10 , V V Tsukanov  11 , S G Burkov  12 , N V Bakulina  13 , N N Dekhnich  14 , L V Tarasova  15 , E Yu Plotnikova  16 , I V Maev  17 , Yu A Kucheryavyi  17 , N V Baryshnikova  18 , M A Butov  19 , S V Kolbasnikov  2 , A L Pakhomova  20 , T V Zhestkova  21 , A Yu Baranovskii  22 , S R Abdulkhakov  8   23 , E A Ageeva  6 , E A Lyalyukova  10 , A V Vasyutin  11 , N N Golubev  12 , I V Savilova  13 , L V Morkovkina  15 , A G Kononova  2 , F Megraud  24 , C O'Morain  25 , M Ramas  26 , O P Nyssen  26 , A G McNicholl  26 , J P Gisbert  26
Affiliations
Observational Study

European Registry on the management of Helicobacter pylori infection (Hp-EuReg): analysis of 2360 patients receiving first-line therapy in Russia

D S Bordin et al. Ter Arkh. .

Abstract

Aim: European Registry on the management of Helicobacter pylori infection («Hp-EuReg») - a multicenter prospective observational study initiated by the European Helicobacter and Microbiota Study Group, conducted in 27 European countries in order to evaluate the real clinical practice of diagnosis and treatment of H. pylori and its comparison with international recommendations.

Materials and methods: The analysis of 2360 patients entered in the register by the Russian centres of «Hp-EuReg» in 2013-2017, who were underwent 1st line eradication therapy.

Results: The most common methods of primary diagnosis of H. pylori are histological (37.7%), rapid urease test (29.2%) and serology (29.7%). The duration of eradication therapy in 9.4% of cases was 7 days, in 65.3% - 10 days, and in 25.3% - 14 days. To control the effec- tiveness of treatment, H. pylori antigen in feces (31.3%), urea breath test (23.4%) and histological method (23.3%) were used. In 3.6% cases was used serology by mistake. In 17.3% of patients control was not carried out. The effectiveness of triple therapy with a PPI, amoxicillin, clar- ithromycin (per protocol) was 67.6%, with 7-day course, 81.1% at 10-day and 86.7% at 14-day course. Eradication rate of triple therapy with addition of bismuth (per protocol) reached 90,6% in the group receiving 10-day scheme and 93.6% in the group receiving the 14-day treatment.

Conclusion: Significant deviations of clinical practice from expert recommendations, most pronounced at the stage of monitoring the effectiveness of therapy, were noted. The suboptimal efficacy of triple therapy is shown.

Keywords: Helicobacter pylori; Hp-EuReg; eradication therapy; register.

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