Renal experiences of bariatric surgery in patients with type 2 diabetes mellitus

Abstract

The review addresses the questions of the literature devoted to the problem of the influence of bariatric surgery on the course of diabetic nephropathy in patients with diabetes mellitus type 2 after achieving a surgically induced remission. This approach was shown to have positive aspects, such as decrease in creatinine, decrease in albuminuria, an increase in GFR, normalization of glycemia and blood pressure, "incretin effect"'s influence on the kidneys. Descriptions of the currently expected pathogenetic mechanisms involved in achieving the observed improvement in microvascular complications of diabetes, namely diabetic kidney disease, are also described in details.

Keywords: bariatric surgery; chronic kidney disease; complications; diabetes mellitus type 2; glucagon-like peptide-1; glucagon-like peptide-1 receptor; incretins; morbid obesity.