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. 2019 Mar 5;58(9):1181-1183.
doi: 10.1021/acs.biochem.9b00012. Epub 2019 Feb 19.

Hexachlorobenzene Catabolism Involves a Nucleophilic Aromatic Substitution and Flavin-N5-Oxide Formation

Sanjoy Adak  1 , Tadhg P Begley  1
Affiliations

Hexachlorobenzene Catabolism Involves a Nucleophilic Aromatic Substitution and Flavin-N5-Oxide Formation

Sanjoy Adak et al. Biochemistry. .

Abstract

HcbA1 is a unique flavoenzyme that catalyzes the first step in the bacterial hexachlorobenzene catabolic pathway. Here we report in vitro reconstitution of the HcbA1-catalyzed reaction. Detailed mechanistic studies provide evidence for nucleophilic aromatic substitution and flavin-N5-oxide formation.

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