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Review
. 2019 Feb;98(5):e14315.
doi: 10.1097/MD.0000000000014315.

Sclerosing pneumocytoma mixed with a typical carcinoid tumor: A case report and review of literature

Zhao Wang  1   2 , Mai-Qing Yang  1   3 , Wen-Jing Huang  1 , Di Zhang  1 , Hong-Tao Xu  1
Affiliations
Review

Sclerosing pneumocytoma mixed with a typical carcinoid tumor: A case report and review of literature

Zhao Wang et al. Medicine (Baltimore). 2019 Feb.

Abstract

Rationale: Sclerosing pneumocytoma accompanied with other type of tumor in one patient is very rare. Here, we report a case of a sclerosing pneumocytoma mixed with a typical carcinoid tumor in a same neoplasm.

Patient concerns: A 55-year-old woman incidentally detected a space-occupying lesion of right lung in routine health examination. The patient was asymptomatic and there were no positive findings in routine laboratory examination, physical examination, and pulmonary function test. Computed tomography revealed a solitary round mass in the middle lobe of the right lung.

Diagnosis: The lesion was diagnosed as a sclerosing pneumocytoma accompanied with a typical carcinoid tumor of the right lung.

Intervention: The patient underwent thoracoscopic lobectomy in our hospital.

Outcomes: The postoperative course was uneventful.

Lessons: This case is rare and noteworthy for a lesion containing two different types of neoplasms, which may cause diagnostic difficulties.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Computed tomograpgy examination of the lung. Computed tomograpgy scan displayed a solitary, well-circumscribed, round mass tumor (arrow) located at the middle lobe of the right lung.
Figure 2
Figure 2
The histological and immunohistochemical features of the present sclerosing pneumocytoma accompanied with typical carcinoid tumor. (A) Typical hemorrhagic and sclerotic regions of the sclerosing pneumocytoma region of the present sclerosing pneumocytoma. (B) Two cell types were observed in the papillary and glandular region of sclerosing pneumocytoma: surface cuboidal cells and stromal round or polygonal cells. (C) A representative field of sclerosing pneumocytoma mixed with carcinoid tumor. The well-arranged cell cords in the center were carcinoid tumor, and periphery papillary and solid regions were sclerosing pneumocytoma. (D) Immunohistochemical staining of broad-spectrum cytokeratin was strongly positive in the cuboidal cells of sclerosing pneumocytoma and weakly positive in carcinoid tumor cells, but negative in the stromal polygonal cells. (E) Immunohistochemical staining of thyroid transcription factor-1 (TTF-1) was positive in both cuboidal surface cells and stromal polygonal cells, but negative in the carcinoid tumor tissue. (F) Immunohistochemical staining of vimentin was positive in the sclerosing pneumocytoma tissue, but negative in the carcinoid tumor tissue. (G) and (H) Immunohistochemical staining of CD56 and synaptophysin were both positive in the carcinoid tumor tissue, but negative in the sclerosing pneumocytoma tissue.
See this image and copyright information in PMC

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