A therapeutic preconceptional vaccine against Chagas disease: A novel indication that could reduce congenital transmission and accelerate vaccine development

doi:10.1371/journal.pntd.0006985

. 2019 Jan 31;13(1):e0006985.

doi: 10.1371/journal.pntd.0006985. eCollection 2019 Jan.

A therapeutic preconceptional vaccine against Chagas disease: A novel indication that could reduce congenital transmission and accelerate vaccine development

Eric Dumonteil¹, Claudia Herrera¹, Pierre Buekens²

Affiliations

¹ Department of Tropical Medicine, School of Public Health and Tropical Medicine, and Vector Borne and Infectious Disease Research Center, Tulane University, New Orleans, Louisiana, United States of America.
² Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America.

PMID: 30703092
PMCID: PMC6354953
DOI: 10.1371/journal.pntd.0006985

A therapeutic preconceptional vaccine against Chagas disease: A novel indication that could reduce congenital transmission and accelerate vaccine development

Eric Dumonteil et al. PLoS Negl Trop Dis. 2019.

. 2019 Jan 31;13(1):e0006985.

doi: 10.1371/journal.pntd.0006985. eCollection 2019 Jan.

Authors

Eric Dumonteil¹, Claudia Herrera¹, Pierre Buekens²

Affiliations

¹ Department of Tropical Medicine, School of Public Health and Tropical Medicine, and Vector Borne and Infectious Disease Research Center, Tulane University, New Orleans, Louisiana, United States of America.
² Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America.

PMID: 30703092
PMCID: PMC6354953
DOI: 10.1371/journal.pntd.0006985

No abstract available

PubMed Disclaimer

Conflict of interest statement

I have read the journal’s policy and the authors of this manuscript have the following competing interests: ED serves as Deputy Editor for PLOS NTDs.

Cited by

Chagas Disease in Europe.
Gonzalez-Sanz M, Crespillo-Andújar C, Chamorro-Tojeiro S, Monge-Maillo B, Perez-Molina JA, Norman FF. Gonzalez-Sanz M, et al. Trop Med Infect Dis. 2023 Dec 1;8(12):513. doi: 10.3390/tropicalmed8120513. Trop Med Infect Dis. 2023. PMID: 38133445 Free PMC article. Review.
Genetic diversity and comparative genomics across Leishmania (Viannia) species.
Gonzalez-Garcia LN, Rodriguez MP, Parra-Muñoz M, Clavijo AM, Levy L, Ovalle-Bracho C, Colorado C, Camargo C, Quiceno E, Moncada MJ, Muskus C, Urrea DA, Baez-Aguirre F, Restrepo S, Echeverry MC, Duitama J. Gonzalez-Garcia LN, et al. Commun Biol. 2025 Jun 14;8(1):925. doi: 10.1038/s42003-025-08331-1. Commun Biol. 2025. PMID: 40517149 Free PMC article.
Immunity and vaccine development efforts against Trypanosoma cruzi.
Rios LE, Vázquez-Chagoyán JC, Pacheco AO, Zago MP, Garg NJ. Rios LE, et al. Acta Trop. 2019 Dec;200:105168. doi: 10.1016/j.actatropica.2019.105168. Epub 2019 Sep 9. Acta Trop. 2019. PMID: 31513763 Free PMC article. Review.
Cruzipain and Its Physiological Inhibitor, Chagasin, as a DNA-Based Therapeutic Vaccine Against Trypanosoma cruzi.
Cerny N, Bivona AE, Sanchez Alberti A, Trinitario SN, Morales C, Cardoso Landaburu A, Cazorla SI, Malchiodi EL. Cerny N, et al. Front Immunol. 2020 Oct 9;11:565142. doi: 10.3389/fimmu.2020.565142. eCollection 2020. Front Immunol. 2020. PMID: 33162979 Free PMC article.
Metallic Nanoparticles and Core-Shell Nanosystems in the Treatment, Diagnosis, and Prevention of Parasitic Diseases.
Król G, Fortunka K, Majchrzak M, Piktel E, Paprocka P, Mańkowska A, Lesiak A, Karasiński M, Strzelecka A, Durnaś B, Bucki R. Król G, et al. Pathogens. 2023 Jun 17;12(6):838. doi: 10.3390/pathogens12060838. Pathogens. 2023. PMID: 37375528 Free PMC article. Review.

See all "Cited by" articles

References

1. WHO. Chagas disease in Latin America: an epidemiological update based on 2010 estimates. Wkly Epidemiol Rec. 2015;90(6):33–43. - PubMed
1. Yadon ZE, Schmunis GA. Congenital Chagas disease: estimating the potential risk in the United States. Am J Trop Med Hyg. 2009;81(6):927–33. 10.4269/ajtmh.2009.09-0257 - DOI - PubMed
1. Lee BY, Bacon KM, Bottazzi ME, Hotez PJ. Global economic burden of Chagas disease: a computational simulation model. Lancet Infect Dis. 2013;13(4):342–8. 10.1016/S1473-3099(13)70002-1 - DOI - PMC - PubMed
1. Rassi A Jr., Marin JAN, Rassi A. Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial. Mem Inst Oswaldo Cruz. 2017:0 10.1590/0074-02760160334 - DOI - PMC - PubMed
1. Dumonteil E, Herrera C. Ten years of Chagas disease research: Looking back to achievements, looking ahead to challenges. PLoS Negl Trop Dis. 2017;11(4):e0005422 10.1371/journal.pntd.0005422 - DOI - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

Grants and funding

R01 HD095857/HD/NICHD NIH HHS/United States

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

[1] WHO. Chagas disease in Latin America: an epidemiological update based on 2010 estimates. Wkly Epidemiol Rec. 2015;90(6):33–43. - PubMed

[2] WHO. Chagas disease in Latin America: an epidemiological update based on 2010 estimates. Wkly Epidemiol Rec. 2015;90(6):33–43. - PubMed

[3] Yadon ZE, Schmunis GA. Congenital Chagas disease: estimating the potential risk in the United States. Am J Trop Med Hyg. 2009;81(6):927–33. 10.4269/ajtmh.2009.09-0257 - DOI - PubMed

[4] Yadon ZE, Schmunis GA. Congenital Chagas disease: estimating the potential risk in the United States. Am J Trop Med Hyg. 2009;81(6):927–33. 10.4269/ajtmh.2009.09-0257 - DOI - PubMed

[5] Lee BY, Bacon KM, Bottazzi ME, Hotez PJ. Global economic burden of Chagas disease: a computational simulation model. Lancet Infect Dis. 2013;13(4):342–8. 10.1016/S1473-3099(13)70002-1 - DOI - PMC - PubMed

[6] Lee BY, Bacon KM, Bottazzi ME, Hotez PJ. Global economic burden of Chagas disease: a computational simulation model. Lancet Infect Dis. 2013;13(4):342–8. 10.1016/S1473-3099(13)70002-1 - DOI - PMC - PubMed

[7] Rassi A Jr., Marin JAN, Rassi A. Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial. Mem Inst Oswaldo Cruz. 2017:0 10.1590/0074-02760160334 - DOI - PMC - PubMed

[8] Rassi A Jr., Marin JAN, Rassi A. Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial. Mem Inst Oswaldo Cruz. 2017:0 10.1590/0074-02760160334 - DOI - PMC - PubMed

[9] Dumonteil E, Herrera C. Ten years of Chagas disease research: Looking back to achievements, looking ahead to challenges. PLoS Negl Trop Dis. 2017;11(4):e0005422 10.1371/journal.pntd.0005422 - DOI - PMC - PubMed

[10] Dumonteil E, Herrera C. Ten years of Chagas disease research: Looking back to achievements, looking ahead to challenges. PLoS Negl Trop Dis. 2017;11(4):e0005422 10.1371/journal.pntd.0005422 - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A therapeutic preconceptional vaccine against Chagas disease: A novel indication that could reduce congenital transmission and accelerate vaccine development

Affiliations

A therapeutic preconceptional vaccine against Chagas disease: A novel indication that could reduce congenital transmission and accelerate vaccine development

Authors

Affiliations

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Medical