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. 2018 Feb;29(1):124-163.
doi: 10.1515/pteridines-2018-0013. Epub 2018 Nov 13.

Periodontal, metabolic, and cardiovascular disease: Exploring the role of inflammation and mental health

Hina Makkar  1 , Mark A Reynolds #  2 , Abhishek Wadhawan  1 , Aline Dagdag  1 , Anwar T Merchant #  3 , Teodor T Postolache #  4
Affiliations

Periodontal, metabolic, and cardiovascular disease: Exploring the role of inflammation and mental health

Hina Makkar et al. Pteridines. 2018 Feb.

Abstract

Previous evidence connects periodontal disease, a modifiable condition affecting a majority of Americans, with metabolic and cardiovascular morbidity and mortality. This review focuses on the likely mediation of these associations by immune activation and their potential interactions with mental illness. Future longitudinal, and ideally interventional studies, should focus on reciprocal interactions and cascading effects, as well as points for effective preventative and therapeutic interventions across diagnostic domains to reduce morbidity, mortality and improve quality of life.

Keywords: Periodontitis; cardiovascular disease; inflammation; mental illness; metabolic syndrome.

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Conflict of interest statement

Conflict of interest: All authors of this paper declare no conflict of interest.

Figures

Figure 1:
Figure 1:
A graphical representation depicting the links between periodontal disease, metabolic diseases, cardiovascular diseases, and mental illness, with inflammation as a common mediator between these disorders. (MetS: Metabolic syndrome; DM: Diabetes mellitus; ASCVD: Atherosclerotic cardiovascular disease; MI: Myocardial infarction; PAD: Peripheral arterial disease).
See this image and copyright information in PMC

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