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. 2019 Jan 17:10:439.
doi: 10.3389/fnagi.2018.00439. eCollection 2018.

Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer's Disease

Virginia Boccardi  1 , Eric Westman  2 , Luca Pelini  1 , Olof Lindberg  2 , J-Sebastian Muehlboeck  2 , Andrew Simmons  3 , Roberto Tarducci  4 , Piero Floridi  5 , Pietro Chiarini  5 , Hilkka Soininen  6 , Iwona Kloszewska  7 , Magda Tsolaki  8 , Bruno Vellas  9 , Christian Spenger  10 , Lars-Olof Wahlund  2 , Simon Lovestone  11 , Patrizia Mecocci  1
Affiliations

Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer's Disease

Virginia Boccardi et al. Front Aging Neurosci. .

Abstract

Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions - in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4. Methods: From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 converter MCI (cMCI) and 119 AD were included. Hippocampal subfield volumes were analyzed using Freesurfer 6.0.0 on high-resolution sagittal 3D-T1W MP-RAGE acquisitions. Plasmatic IL-4 was measured using ELISA assay. Results: IL-4 was found to be (a) positively associate with left subiculum volume (β = 0.226, p = 0.037) in sMCI and (b) negatively associate with left subiculum volume (β = -0.253, p = 0.011) and left presubiculum volume (β = -0.257, p = 0.011) in AD. Conclusion: Our results indicate a potential neuroprotective effect of IL-4 on the areas of the hippocampus more vulnerable to aging and neurodegeneration.

Keywords: Alzheimer’s disease; aging; inflammation; inflammatory markers; mild cognitive impairment.

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